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Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP  CHEST 

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Presentation on theme: "Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP  CHEST "— Presentation transcript:

1 Targeted Therapy for the Treatment of Advanced Non-small Cell Lung Cancer 
Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP  CHEST  Volume 128, Issue 6, Pages (December 2005) DOI: /chest Copyright © 2005 The American College of Chest Physicians Terms and Conditions

2 Figure 1 EGFR signaling pathway Akt = anti-apoptotic downstream cellular kinase; PI3K = phosphatidylinositol 3 kinase; PKC = protein kinase C; Grb2 = growth factor receptor bound protein-2; Sos = son of sevenless; MAPK = mitogen-activated protein kinase. CHEST  , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Rates of symptom improvement in the IDEAL trials.2526
CHEST  , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Rate of symptom improvement from onset of medication for patients who experienced improvement in the IDEAL-2 trial.26 CHEST  , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Association of symptom improvement and survival in the IDEAL trials CHEST  , DOI: ( /chest ) Copyright © 2005 The American College of Chest Physicians Terms and Conditions


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