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Nanocell Intro of Drug Delivery System What is nanocell Marketing

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Presentation on theme: "Nanocell Intro of Drug Delivery System What is nanocell Marketing"— Presentation transcript:

1 Nanocell Intro of Drug Delivery System What is nanocell Marketing
Ethics Mechanism Ms. Soraya Synthesis Ms. Titima In vivo In vitro Dr. Panthee Clinical trial Summary Ms. Chanokkamon Dr. Bonduush

2 Introduction, Marketing part and Ethical issues
Nanocell: Introduction, Marketing part and Ethical issues Ms Chanokkamon Cheawtada Inter-U program AIT

3 Scope: Marketing and Ethics
Drug delivery system General cancer Liver cancer treatment Conventional drug for treat liver cancer Problems of conventional drug What is “nanocell”? Advantage of nanocell Compare cost-benefit between conventional drug and nanocell Using Calculation for profit cost for developing country (Ethics)

4 Drug delivery system for cancer
Drug targeting of tumors Maximize drug potency Minimize systemic toxicity. Drug carrier Route of administation ●Liposome composed of one or more phospholipid bilayer Intravenous(iv)injection e.g. liposome entrapped doxorubicin ●Bead e.g. drug-eluting microspheres/beads Hepatic artery (DEB) load with doxorubicin ●Prodrug e.g prodrug of cisplatin using dextran Intravenous(iv)injection (galactose unit)

5 Liver cancer treatment
Localized unresectable Localized resectable Segmental resection - Trisegmental resection liver transplantation Systemic chemotherapy Tumor embolization Chemoembolization Hormone therapy Radiolabeled Recurrent

6 Conventional drugs Doxorubicin IV injection IV infusion
. Doxorubicin IV injection 60-90 mg/m2- every 3 weeks 20-30 mg/m2/day - 3 days every 3 to 4 weeks. Dose depends upon which regimen for cancer is being Poor risk patient Reduce dosage IV infusion 60-75 mg/m2 - every 3 weeks From

7 Conventional drugs 5-FU Oral IV injection (capecitabine) 1250 mg/m2
every 5 days repeated every 4 weeks (28-day) Oral (capecitabine) 1250 mg/m2 twice daily 2 weeks 1 week rest From

8 Conventional drugs Cisplatin IV infusion 50-100 mg/m2 every 3-4 week
daily for 5 days/week for 3-4 week. From

9 Conventional drugs Combretastatin IV infusions 52 mg/m2
On day 1, 8, and 15. courses repeat every 28 days From:

10 Problem of conventional drug
Many side effect - Drug effect on normal cell e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea, Less effective - Drug cannot get into only liver but effect other organ Too complicate in treatment - For treat liver cancer use series of drug for more effectiveness Series of drug - take time for inject the drugs - very painful because use large dose Expensive Drug resistance

11 From:http://www.medicalillustrator.com

12 Nanocell Nanocell is small particle between 10-1000nm.
- less than 200 nm. - Can pass through tumor blood vessels - The outer shell anti-angiogenesis - The inner core chemotherapy drugs. - A "stealth" surface - avoid immune system

13 From From:http://www.medicalillustrator.com

14 From:http://www.medicalillustrator.com, http://www.3d4medical.com

15 Advantages of Nanocell
Directly to the target site ( liver cancer) Less side effect - Not effect on normal cell Not complicate for treatment - Inject only one time in one cycle of treatment More effective Less invasive - less pianful - less injection time Economic price Easy to inject - IV injection

16 Compare Cost-benefit Drug Dose Duration (1cycle) Price ($) (6-8cycle)
Doxorubicin - IV injection - IV infusion 60-90 mg/m2 20-30 mg/m2 60-75 mg/m2 every 3 weeks every day- 3 days every 3 to 4 weeks 8,501.76 7,084.80 5-fu - Oral 400 mg/m2 1250 mg/m2 every day- 5 days repeated at 4 weeks twice daily 2 weeks 1 week rest 11,808.00 11,336.22 Cisplatin mg/m2 15-20 mg/m2 every 3 to 4 week daily 5 days/week for 3 to 4weeks 227.78 Combretastatin 52or68mg/m2 On day 1, 8, and 15 every 28 days 38,304.04 Nanocell 100µl/kgBW every 4 weeks 4,546.89 https://www.sigmaaldrich.com,

17 Calculation profit Sale Capital (US$) Revenue Sale price
Profit (1person ) (US$) Retail 2,393.10 90% 4,546.89 2,153.79 Wholesale 50% 3,589.65 1,196.55

18 Ethical issues Liver cancer population Almost countries in Asia are
- high incidence in Asia. Almost countries in Asia are - developing countries Almost developing countries have - a large number of poor people e.g. Thai GDP per capita income 2,221 US$ “Nanocell for developing countries” - economic price

19 Nanocell for developing countries
11,868 persons 1995 – 1997 Sriamporn, et al(2002)

20 Summary So nanocell has been made for solving those problems of the conventional drugs For its price, there are two target groups which are: - the developing countries such as Thailand, Indonesia , it will be sold at whole sale - the other countries at the retail.

21 Addition Body surface area in m2 =
√ { height (cm) x weight (kg) }/3600 = m2 Standard WHO wieght 70 kg Hight 1.75 metre (from Norgan 1994)


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