1. Nanocell Intro of Drug Delivery System What is nanocell Marketing
Ethics
Mechanism Ms. Soraya
Synthesis Ms. Titima
In vivo In vitro Dr. Panthee
Clinical trial
Summary
Ms. Chanokkamon
Dr. Bonduush

2. Introduction, Marketing part and Ethical issues
Nanocell:
Introduction, Marketing part
and Ethical issues
Ms Chanokkamon Cheawtada
Inter-U program AIT

3. Scope: Marketing and Ethics
Drug delivery system
General cancer
Liver cancer treatment
Conventional drug for treat liver cancer
Problems of conventional drug
What is “nanocell”?
Advantage of nanocell
Compare cost-benefit between conventional drug and nanocell
Using Calculation for profit cost for developing country (Ethics)

4. Drug delivery system for cancer
Drug targeting of tumors
Maximize drug potency
Minimize systemic toxicity.
Drug carrier Route of administation
●Liposome
composed of one or more phospholipid bilayer Intravenous(iv)injection
e.g. liposome entrapped doxorubicin
●Bead
e.g. drug-eluting microspheres/beads Hepatic artery
(DEB) load with doxorubicin
●Prodrug
e.g prodrug of cisplatin using dextran Intravenous(iv)injection
(galactose unit)

5. Liver cancer treatment
Localized unresectable
Localized resectable
Segmental resection -
Trisegmental resection
liver transplantation
Systemic chemotherapy
Tumor embolization
Chemoembolization
Hormone therapy
Radiolabeled
Recurrent

6. Conventional drugs Doxorubicin IV injection IV infusion.
Doxorubicin
IV injection
60-90 mg/m2- every 3 weeks
20-30 mg/m2/day - 3 days
every 3 to 4 weeks.
Dose depends upon which
regimen for cancer is being
Poor risk patient Reduce dosage
IV infusion
60-75 mg/m2
- every 3 weeks
From

7. Conventional drugs 5-FU Oral IV injection (capecitabine) 1250 mg/m2
every 5 days
repeated every
4 weeks (28-day)
Oral
(capecitabine)
1250 mg/m2
twice daily 2 weeks
1 week rest
From

8. Conventional drugs Cisplatin IV infusion 50-100 mg/m2 every 3-4 week
daily for 5 days/week
for 3-4 week.
From

9. Conventional drugs Combretastatin IV infusions 52 mg/m2
On day 1, 8, and 15.
courses repeat
every 28 days
From:

10. Problem of conventional drug
Many side effect
- Drug effect on normal cell
e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea,
Less effective
- Drug cannot get into only liver but effect other organ
Too complicate in treatment
- For treat liver cancer use series of drug for more effectiveness
Series of drug
- take time for inject the drugs
- very painful because use large dose
Expensive
Drug resistance

11. From:

12. Nanocell Nanocell is small particle between 10-1000nm.
- less than 200 nm.
- Can pass through tumor blood vessels
- The outer shell anti-angiogenesis
- The inner core chemotherapy drugs.
- A "stealth" surface
- avoid immune system

13. From
From:

14. From:http://www.medicalillustrator.com, http://www.3d4medical.com

15. Advantages of Nanocell
Directly to the target site ( liver cancer)
Less side effect
- Not effect on normal cell
Not complicate for treatment
- Inject only one time in one cycle of treatment
More effective
Less invasive
- less pianful
- less injection time
Economic price
Easy to inject
- IV injection

16. Compare Cost-benefit Drug Dose Duration (1cycle) Price ($) (6-8cycle)
Doxorubicin
- IV injection
- IV infusion
60-90 mg/m2
20-30 mg/m2
60-75 mg/m2
every 3 weeks
every day- 3 days every 3 to 4 weeks
8,501.76
7,084.80
5-fu
- Oral
400 mg/m2
1250 mg/m2
every day- 5 days repeated at 4 weeks
twice daily 2 weeks 1 week rest
11,808.00
11,336.22
Cisplatin
mg/m2
15-20 mg/m2
every 3 to 4 week
daily 5 days/week for 3 to 4weeks
227.78
Combretastatin
52or68mg/m2
On day 1, 8, and 15 every 28 days
38,304.04
Nanocell
100µl/kgBW
every 4 weeks
4,546.89

17. Calculation profit Sale Capital (US$) Revenue Sale price
Profit (1person ) (US$)
Retail
2,393.10
90%
4,546.89
2,153.79
Wholesale
50%
3,589.65
1,196.55

18. Ethical issues Liver cancer population Almost countries in Asia are
- high incidence in Asia.
Almost countries in Asia are
- developing countries
Almost developing countries have
- a large number of poor people
e.g. Thai GDP per capita income 2,221 US$
“Nanocell for developing countries”
- economic price

19. Nanocell for developing countries
11,868 persons
1995 – 1997
Sriamporn, et al(2002)

20. Summary
So nanocell has been made for solving those problems of the conventional drugs
For its price, there are two target groups
which are:
- the developing countries such as Thailand, Indonesia , it will be sold at whole sale
- the other countries at the retail.

21. Addition Body surface area in m2 =
√ { height (cm) x weight (kg) }/3600
= m2
Standard WHO
wieght 70 kg
Hight 1.75 metre
(from Norgan 1994)