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Nanocell Intro of Drug DeliverySystemIntro of Drug DeliverySystem What is nanocellWhat is nanocell MarketingMarketing EthicsEthics MechanismMs. SorayaMechanismMs.

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Presentation on theme: "Nanocell Intro of Drug DeliverySystemIntro of Drug DeliverySystem What is nanocellWhat is nanocell MarketingMarketing EthicsEthics MechanismMs. SorayaMechanismMs."— Presentation transcript:

1 Nanocell Intro of Drug DeliverySystemIntro of Drug DeliverySystem What is nanocellWhat is nanocell MarketingMarketing EthicsEthics MechanismMs. SorayaMechanismMs. Soraya SynthesisMs. TitimaSynthesisMs. Titima In vivo In vitroDr. PantheeIn vivo In vitroDr. Panthee Clinical trialClinical trial SummarySummary Ms. Chanokkamon Dr. Bonduush

2 Nanocell: Introduction, Marketing part and Ethical issues Ms Chanokkamon Cheawtada Inter-U program AIT

3 Scope: Marketing and Ethics Drug delivery systemDrug delivery system –General cancer Liver cancer treatmentLiver cancer treatment Conventional drug for treat liver cancerConventional drug for treat liver cancer Problems of conventional drugProblems of conventional drug What is nanocell?What is nanocell? Advantage of nanocellAdvantage of nanocell Compare cost-benefit between conventional drug and nanocellCompare cost-benefit between conventional drug and nanocell Using Calculation for profit cost for developing country (Ethics)Using Calculation for profit cost for developing country (Ethics)

4 Drug delivery system for cancer Drug targeting of tumorsDrug targeting of tumors Maximize drug potencyMaximize drug potency Minimize systemic toxicityMinimize systemic toxicity. Drug carrier Route of administationDrug carrier Route of administation Liposome composed of one or more phospholipid bilayer Intravenous(iv)injection composed of one or more phospholipid bilayer Intravenous(iv)injection - e.g. liposome entrapped doxorubicin Bead -e.g. drug-eluting microspheres/beads Hepatic artery (DEB) load with doxorubicin Prodrug -e.g prodrug of cisplatin using dextran Intravenous(iv)injection (galactose unit)

5 Liver cancer treatment Liver cancer Localized unresectable Localized resectable liver transplantation Systemic chemotherapy Tumor embolization Chemoembolization Hormone therapy Radiolabeled Segmental resection - Trisegmental resection Recurrent

6 Conventional drugs. Doxorubicin IV injection mg/m2- every 3 weeks mg/m2/day - 3 days every 3 to 4 weeks. Dose depends upon which regimen for cancer is being regimen for cancer is being Poor risk patient Reduce dosage IV infusion mg/m2 - every 3 weeks From

7 Conventional drugs 5-FU IV injection 400 mg/m2 every 5 days every 5 days repeated every 4 weeks (28-day) Oral(capecitabine) 1250 mg/m2 twice daily 2 weeks 1 week rest From

8 Conventional drugs Cisplatin IV infusion mg/m2 every 3-4 week mg/m2 daily for 5 days/week for 3-4 week. From

9 Conventional drugs Combretastatin IV infusions 52 mg/m2 On day 1, 8, and 15. courses repeat every 28 days From:

10 Problem of conventional drug Many side effectMany side effect - Drug effect on normal cell - Drug effect on normal cell e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea, Less effectiveLess effective - Drug cannot get into only liver but effect other organ Too complicate in treatmentToo complicate in treatment - For treat liver cancer use series of drug for more effectiveness Series of drugSeries of drug - take time for inject the drugs - very painful because use large dose ExpensiveExpensive Drug resistanceDrug resistance

11 From:http://www.medicalillustrator.com

12 Nanocell Nanocell is small particle between nm.Nanocell is small particle between nm. - less than 200 nm. - Can pass through tumor blood vessels - The outer shell anti-angiogenesis - The inner core chemotherapy drugs. - A "stealth" surface - avoid immune system

13 From:

14 From:http://www.medicalillustrator.com,

15 Advantages of Nanocell Directly to the target site ( liver cancer)Directly to the target site ( liver cancer) Less side effectLess side effect - Not effect on normal cell Not complicate for treatmentNot complicate for treatment -Inject only one time in one cycle of treatment More effectiveMore effective Less invasiveLess invasive - less pianful -less injection time Economic priceEconomic price Easy to injectEasy to inject - IV injection

16 Compare Cost-benefit DrugDose Duration (1cycle) Price ($) (6-8cycle) Doxorubicin - IV injection - IV injection - IV infusion - IV infusion mg/m mg/m mg/m2 every 3 weeks every day- 3 days every 3 to 4 weeks every 3 weeks 8, , , fu - IV injection - IV injection - Oral - Oral 400 mg/m mg/m2 every day- 5 days repeated at 4 weeks twice daily 2 weeks 1 week rest 11, , Cisplatin - IV infusion - IV infusion mg/m mg/m2 every 3 to 4 week daily 5 days/week for 3 to 4weeks Combretastatin - IV infusion - IV infusion mg/m2 52or68mg/m2On day 1, 8, and 15 every 28 days38, Nanocell - IV infusion - IV infusion 100µl/kgBW every 4 weeks 4, https://www.sigmaaldrich.com, https://www.sigmaaldrich.com,

17 Calculation profitSale Capital Capital (US$ (US$)Revenue Sale price (US$ (US$) Profit (1person ) (US$ Profit (1person ) (US$) Retail2, % 4, , , Wholesale2, %3, ,196.55

18 Ethical issues Liver cancer populationLiver cancer population - high incidence in Asia. Almost countries in Asia areAlmost countries in Asia are - developing countries Almost developing countries have Almost developing countries have - a large number of poor people e.g. Thai GDP per capita income 2,221 US$ Nanocell for developing countriesNanocell for developing countries -economic price -economic price

19 Nanocell for developing countries 11,868 persons 1995 – 1997 Sriamporn, et al(2002)

20 Summary So nanocell has been made for solving those problems of the conventional drugs For its price, there are two target groups which are: -the developing countries such as Thailand, Indonesia, it will be sold at whole sale -the other countries at the retail.

21 Addition Body surface area in m2 = { height (cm) x weight (kg) }/3600 { height (cm) x weight (kg) }/3600 = m2 Standard WHO wieght 70kg Hight1.75 metre (from Norgan 1994)


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