1. Ephrin-A2 and Ephrin-A5 Are Important for the Functional Development of Cutaneous Innervation in a Mouse Model 
Dulharie T. Wijeratne, Jennifer Rodger, Hilary J. Wallace, Siaavash Maghami, Matthew Sykes, Fiona M. Wood, Mark W. Fear 
Journal of Investigative Dermatology 
Volume 135, Issue 2, Pages (February 2015)
DOI: /jid
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2. Figure 1
Interfollicular cutaneous innervation of Ephrin-A-/- and wild-type mice. (a–c) Interfollicular dermal nerve density in wild type, Ephrin-A2-/-, Ephrin-A5-/-, and Ephrin-A2A5-/- genotypes at P1 (a), P19 (b), and in adults (c). (d–f) Interfollicular epidermal nerve density in wild type, Ephrin-A2-/-, Ephrin-A5-/-, and Ephrin-A2A5-/- genotypes at P1 (d), P19 (e), and in adults (f). (g–r) Cutaneous epidermal and dermal nerves labeled with PGP 9.5 (marked with arrows) in wild type at P1 (g), Ephrin-A2-/- at P1(h), Ephrin-A5-/- at P1(i), Ephrin-A2A5-/- at P1 (j), wild type at P19 (k), Ephrin-A2-/- at P19 (l), Ephrin-A5-/- at P19 (m), Ephrin-A2A5-/- at P19 (n), adult wild type (o), adult Ephrin-A2-/- (p), adult Ephrin-A5-/- (q), and adult Ephrin-A2A5-/- (r). *P⩽0.05, **P⩽0.01, and ***P⩽ Hair follicles are marked with arrowheads. Scale bar=50 μm.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Interfollicular dermal and epidermal nerve density over time and sensory function in Ephrin A-/- and wild-type mice. (a–d) Interfollicular dermal nerve densities of wild type (a), Ephrin-A2-/- (b), Ephrin-A5-/- (c), Ephrin-A2A5-/- (d), genotypes across P1, P19, and adult stages. (e–h). Interfollicular epidermal nerve densities of wild type (e), Ephrin-A2-/- (f), Ephrin-A5-/- (g), Ephrin-A2A5-/- (h), genotypes across P1, P19, and adult stages. *P⩽0.05, **P⩽0.01, and ***P⩽ (i) The touch sensitivity of Ephrin-A5-/- mice was significantly increased for 50% touch sensitivity threshold. *P<0.05 and **P<0.01. Ephrin-A5-/- mice were significantly less sensitive compared with wild-type (P=0.002), Ephrin-A2-/- (P=0.003), and Ephrin-A2A5-/- (P=0.024) mice.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions