1. Eosinophil Recruitement
FIRST EXPOSURE
Interleukins 4&5
IgE Antibodies
Epithelial
Damage
Eotoxins
IgE Fc Receptor
Interleukins 3&5
Eosinophil Recruitement
Mast Cells
Activation
Smooth Muscle Spasm
Release of Granules & Mediators
Fc receptor is a protein found on the surface of certain cells.
Granules and mediators include HISTAMINES, LEUKOTRIENES AND PROSTAGLANDINS. Release of granules and mediators causes itching and skin rashes. Treatment will be antihistaminics, leukotriene inhibitors or mast cells inhibitors.
Smooth muscle spasm in addition to edema can cause breathing difficulty. Antihistaminics,mast cells inhibitors, steroids, vasodilators will be included in the treatment.
Mucus secretion will include decongestants and anticholinergics for the treatment in addition to other allergy medicines.
SUBSEQUENT EXPOSURE
Release of Primary & Secondary Mediators
Blood Vessel
Mucus Secretion
Leucocyte Infiltration
Edema

2. Production of IgE Antibodies

3. Allergen Cross-linkage of IgE to Fc Receptors

4. Allergic Mechanism