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Enzymes. Enzyme Active Site Amino acid side chains interact, metal ions, Various types of polar, non-polar, ionic interactions.

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Presentation on theme: "Enzymes. Enzyme Active Site Amino acid side chains interact, metal ions, Various types of polar, non-polar, ionic interactions."— Presentation transcript:

1 Enzymes

2 Enzyme Active Site Amino acid side chains interact, metal ions, Various types of polar, non-polar, ionic interactions

3 Enzyme Active Site Amino acid side chains interact, metal ions, Various types of polar, non-polar, ionic interactions

4 Enzymes Lock and Key Analogy: lock = enzyme, key = substrate.

5 Enzymes Lock and Key Analogy: lock = enzyme, key = substrate.

6 Induced Fit Theory Enzyme is not rigid, changes shape with substrate.

7 Induced Fit Theory Enzyme is not rigid, changes shape with substrate.

8 Enzymes - Cofactors Coenzymes (contain a vitamin) or metal ion

9 Enzymes - Cofactors Metal ions present in trace amounts

10 Enzymes - Cofactors Metal ions present in trace amounts

11 Enzyme Cofactors Coenzyme - non protein organic, maybe a vitamin.

12 Enzyme Cofactors Coenzyme - non protein organic, maybe a vitamin.

13 Enzyme Cofactors Coenzyme - non protein organic, maybe a vitamin.

14 Enzymes

15 Enzymes - Activity Temperature and pH effect enzyme action

16 Enzymes - Activity Temperature and pH effect enzyme action

17 Enzymes - Activity Enzyme and substrate concentrations

18 Enzymes - Inhibitors Nonspecific - denaturation, pH, temperature

19 Enzyme Inhibitors Noncompetitive

20 Enzyme Inhibitors Competive - mimic substrate, may block active site, but may dislodge it.

21 Enzyme Inhibitors Competive - mimic substrate, may block active site, but may dislodge it.

22 Enzyme Inhibitors

23 Irreversible - covalently binds to active site

24 Enzyme Inhibitors Regulator or feedback - used to control a sequence of reactions - reaction product may block initial enzyme.

25 Enzyme Inhibitors Regulator or feedback - used to control a sequence of reactions - reaction product may block initial enzyme.

26 Enzyme Inhibitors

27

28 Drugs as Enzyme Inhibitors Drug mimics some natural chemical to block enzyme.

29 Drugs as Enzyme Inhibitors Drug mimics some natural chemical to block enzyme.


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