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Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence  Rebecca S. Gruchalla,

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Presentation on theme: "Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence  Rebecca S. Gruchalla,"— Presentation transcript:

1 Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence  Rebecca S. Gruchalla, MD, PhD, Hugh A. Sampson, MD, Elizabeth Matsui, MD, Gloria David, PhD, MHSc, Peter J. Gergen, MD, MPH, Agustin Calatroni, MA, MS, Mark Brown, MD, Andrew H. Liu, MD, Gordon R. Bloomberg, MD, James F. Chmiel, MD, Rajesh Kumar, MD, Carin Lamm, MD, Ernestine Smartt, RN, Christine A. Sorkness, PharmD, Suzanne F. Steinbach, MD, Kelly D. Stone, MD, PhD, Stanley J. Szefler, MD, William W. Busse, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 2, Pages e1 (August 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Relative importance of baseline characteristics for predicting maximum symptom days (A) and exacerbations (B) during follow-up (visits 3-8). Combined, these baseline characteristics explain 11.4% and 12.6% of the variation for maximum symptom days and exacerbations, respectively. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Relative importance of baseline characteristics for predicting baseline FENO. A, Individual variables. B, Variables combined into specific domains with 95% CI. Domains are defined as lung function (methacholine PC20, FEV1/FVC, FEV1% predicted, and postbronchodilator percent change in FEV1), inflammation (blood and sputum eosinophils), atopy (number of positive skin tests, total IgE, and sum of the 5 allergen-specific IgEs), and symptoms (maximum symptom days, days of albuterol use, nights of albuterol use, and exacerbations). Combined, these baseline characteristics explain 50.3% of the variation in FENO. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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