Presentation is loading. Please wait.

Presentation is loading. Please wait.

Asthma phenotypes in inner-city children

Published byRobert Atkinson Modified over 6 years ago

Similar presentations

Presentation on theme: "Asthma phenotypes in inner-city children"— Presentation transcript:

1 Asthma phenotypes in inner-city children
Edward M. Zoratti, MD, Rebecca Z. Krouse, MS, Denise C. Babineau, PhD, MS, Jacqueline A. Pongracic, MD, George T. O'Connor, MD, MS, Robert A. Wood, MD, Gurjit K. Khurana Hershey, MD, PhD, Carolyn M. Kercsmar, MD, Rebecca S. Gruchalla, MD, PhD, Meyer Kattan, MD, Stephen J. Teach, MD, MPH, Steven M. Sigelman, RN, MHA, Peter J. Gergen, MD, MPH, Alkis Togias, MD, Cynthia M. Visness, PhD, William W. Busse, MD, Andrew H. Liu, MD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 4, Pages (October 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Journal of Allergy and Clinical Immunology 2016 138, 1016-1029DOI: (10
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 Dendrogram produced by the HCA. Participants in clusters A, B, C, D, and E are denoted by the colors red, blue, green, purple, and orange, respectively. The y-axis is a measure of dissimilarity between clusters such that the greater the height at which 2 clusters break off from one another, the greater the dissimilarity between the 2 clusters. The gray line indicates the height of the 5-cluster solution, as it cuts through 5 vertical lines, each of which represents a cluster. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 2 Variable importance plot of characteristics distinguishing the clusters. Bars plot the median z score for each variable, a measure of importance obtained from a feature selection algorithm called Boruta where higher values indicate a higher level of importance. Only those variables that were confirmed as relevant to distinguishing between the 5 clusters are presented in this figure. ACT/cACT, Asthma Control Test/Childhood Asthma Control Test; CASI, Composite Asthma Severity Index. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 3 Descriptive summary indicating the relative degree to which asthma, pulmonary physiology, rhinitis, and allergy-related variables were present in each cluster. The graded color scheme contains 5 shades of blue, representing the 20th (lightest), 40th, 60th, 80th, and 100th (darkest) percentiles of the data for each row. Overall P values indicating differences between the 5 clusters are P < .0001 for all variables. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 4 Characteristics related to allergy by cluster. Categorical variables are summarized by bar charts with whiskers for standard errors. Continuous variables are summarized by notched boxplots, such that the box represents the interquartile range, the whiskers add/subtract 1.5 times the 75th/25th percentiles, the line represents the median, and the notch represents the 95% CI around the median. For continuous variables, the mean number of allergen sensitizations or geometric mean of total serum IgE is represented by the black dot. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 5 Characteristics of pulmonary physiology and inflammatory biomarkers by cluster. Categorical variables are summarized by barcharts with whiskers for standard errors. Continuous variables are summarized by notched boxplots, such that the box represents the interquartile range, the whiskers add/subtract 1.5 times the 75th/25th percentiles, the line represents the median, and the notch represents the 95% CI around the median. For continuous variables, mean FEV1/FVC (×100) or geometric mean Feno is represented by the black dot, with the exception of blood eosinophils and PC20, where median value is most appropriate. CASI, Composite Asthma Severity Index. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig 6 Characteristics of asthma symptoms, exacerbations, and treatment by cluster. Categorical variables are summarized by bar charts with whiskers for standard errors. Continuous variables are summarized by notched boxplots, such that the box represents the interquartile range, the whiskers add/subtract 1.5 times the 75th/25th percentiles, the line represents the median, and the notch represents the 95% CI around the median. For continuous variables, the black dot indicates the mean value. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig 7 Characteristics of rhinitis by cluster. Categorical variables are summarized by bar charts with whiskers for standard errors. Continuous variables are summarized by notched boxplots, such that the box represents the interquartile range, the whiskers add/subtract 1.5 times the 75th/25th percentiles, the line represents the median, and the notch represents the 95% CI around the median. For rhinitis symptom score, the black dot indicates the mean value. A detailed algorithm describing rhinitis medication management during the APIC study can be found in Pongracic et al.12 ACT/cACT, Asthma Control Test/Childhood Asthma Control Test; CASI, Composite Asthma Severity Index. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Asthma phenotypes in inner-city children"

Similar presentations

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.
Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children  Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children  Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.
Journal of Allergy and Clinical Immunology

Journal of Allergy and Clinical Immunology
Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.
Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A

Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk  J. Andrew Bird, MD, Julie Wang, MD, Cynthia.

Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk  J. Andrew Bird, MD, Julie Wang, MD, Cynthia.
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy  Rosalind J.

Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy  Rosalind J.
Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence  Rebecca S. Gruchalla,

Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherence  Rebecca S. Gruchalla,
Alalia Berry, MD, William W. Busse, MD 

Alalia Berry, MD, William W. Busse, MD 
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.
Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children  Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children  Susan V. Lynch, PhD, Robert A. Wood, MD, Homer.
Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison  Danilo Di.

Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison  Danilo Di.
The nasal methylome and childhood atopic asthma

The nasal methylome and childhood atopic asthma
Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma  Ioana Agache, MD, PhD, Daniel S. Strasser, PhD,

Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma  Ioana Agache, MD, PhD, Daniel S. Strasser, PhD,
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Katherine J. Baines, PhD, BBiomedSci (Hons), Jodie L

Katherine J. Baines, PhD, BBiomedSci (Hons), Jodie L

Similar presentations

Ads by Google