1. Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma 
Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD, Vernon M. Chinchilli, PhD, Timothy J. Craig, DO, Avery August, PhD, Faoud T. Ishmael, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 137, Issue 5, Pages (May 2016)
DOI: /j.jaci
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
miRNA expression in healthy, allergic, and asthmatic subjects. A, Heat map showing expression of 39 candidate miRNAs in 19 healthy, 25 allergic, and 35 asthmatic subjects after 2-way unsupervised hierarchical clustering. B, Representative box plots showing differential expression patterns of miRNAs among healthy, allergic, and asthmatic cohorts. miR-937 is shown as a nondifferentially expressed miRNA.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Predicted inflammatory gene targets of miRNAs. Selected inflammatory genes targeted by each group of miRNAs are depicted in a network diagram. Differentially expressed miRNAs that do not target any of the selected genes are not shown.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Cluster analysis of miRNA expression in asthmatic patients. A, Heat map showing 2 main clusters of miRNA expression in asthmatic patients. B, Box plot of peripheral eosinophil levels in clusters 1 and 2.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
Results of the random forest model with 6 features and 100 decision trees. A, Plot describing the proportion of each predicted phenotype for subjects of each disease status. B, Multiclass receiver operating characteristic curve analysis with pairwise comparisons of one class versus all other classes. The average area under the curve (AUC) for the 3 receiver operating characteristic curves is , indicating that the model performs well in discriminating between positive and negative instances.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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6. Fig E1
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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7. Fig E2
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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8. Fig E3
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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9. Fig E4
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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10. Fig E5
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
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11. Fig E6
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions