Presentation is loading. Please wait.

Presentation is loading. Please wait.

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.

Published byMarian Hoover Modified over 6 years ago

Similar presentations

Presentation on theme: "Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L."— Presentation transcript:

1 Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L. Fuhlbrigge, MD, Robert C. Strunk, MD, Robert S. Zeiger, MD, Scott T. Weiss, MD, Benjamin A. Raby, MD  Journal of Allergy and Clinical Immunology  Volume 133, Issue 5, Pages e12 (May 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Kaplan-Meier plots by cluster of the cumulative probability of a first course of prednisone (A) or initiation of additional asthma controller therapies (beclomethasone or other; B) during the 4-year follow-up period of the CAMP trial. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Mean pulmonary function measurements for each phenotypic cluster evaluated over 48 months of follow-up. P values for between-cluster differences among all longitudinal measures were less than .0001, as calculated by using linear mixed-effects models. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Kaplan-Meier estimate by treatment group of the cumulative probability of prednisone use during 4 years of follow-up stratified by phenotypic cluster. B, Budesonide; N, Nedocromil. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E1 A, The gap statistic as a function of the number of clusters. A higher gap statistic indicates greater between-cluster separation. B, Heat map depicting the differences among normalized clinical variables used for clustering and the different phenotypic clusters. The cluster assignments are grouped along the horizontal axis, and the variables used to determine the cluster assignments appear along the vertical axis. The lighter shades of blue denote relatively higher magnitudes for each variable, and the darker shades denote relatively lower magnitudes. *P < for difference in distribution across clusters. Variables demonstrating more distinct between-cluster differences in magnitude, such as hospital history, AD, PC20, and hay fever history, were the primary drivers of the cluster assignments. BD, Bronchodilator. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E2 Kaplan-Meier plots by cluster of the cumulative probability of a first course of prednisone during the 4-year follow-up period of the CAMP trial. Clusters were determined based on a single clinical variable indicated at the top of each figure. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E2 Kaplan-Meier plots by cluster of the cumulative probability of a first course of prednisone during the 4-year follow-up period of the CAMP trial. Clusters were determined based on a single clinical variable indicated at the top of each figure. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E3 Comparison of phenotypic clusters generated by means of hierarchical clustering (new clusters) versus spectral clustering (old clusters). A, Comparison of study subject cluster assignments. B, Survival analysis for time to first use of prednisone (left) and time to use of additional asthma controller therapy (right) for hierarchical clusters. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L."

Similar presentations

Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.

Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
The natural history of soy allergy

The natural history of soy allergy
Advances in Diagnosing Peanut Allergy

Advances in Diagnosing Peanut Allergy
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy  Satya D. Narisety,
Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,
Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B
Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma  Anand C. Patel, MD, Mark L. Van Natta, MHS, James.

Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma  Anand C. Patel, MD, Mark L. Van Natta, MHS, James.
Anne L. Fuhlbrigge, MD, MS, Seung Jin Bae, MS, MPharm, Scott T

Anne L. Fuhlbrigge, MD, MS, Seung Jin Bae, MS, MPharm, Scott T
Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD 

Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD 
Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial  Christine A. Sorkness,

Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial  Christine A. Sorkness,
Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications  Judie A. Howrylak, MD, Anne L.
Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from.

Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from.
Decreased response to inhaled steroids in overweight and obese asthmatic children  Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,

Decreased response to inhaled steroids in overweight and obese asthmatic children  Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,
Katherine J. Baines, PhD, BBiomedSci (Hons), Jodie L

Katherine J. Baines, PhD, BBiomedSci (Hons), Jodie L
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,
Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point  Emma C.Y. Hilton, PhD, Paul G.

Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point  Emma C.Y. Hilton, PhD, Paul G.
Safety of formoterol in patients with asthma: Combined analysis of data from double- blind, randomized controlled trials  Harold Nelson, MD, Catherine.

Safety of formoterol in patients with asthma: Combined analysis of data from double- blind, randomized controlled trials  Harold Nelson, MD, Catherine.

Similar presentations

Ads by Google