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Figure 4. Inhibition of LPS-induced IL-1β and TNFα, but not IL-6, after exercise. Depicted are LPS-induced IL-1β (upper panel), IL-6 (middle panel), and.

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Presentation on theme: "Figure 4. Inhibition of LPS-induced IL-1β and TNFα, but not IL-6, after exercise. Depicted are LPS-induced IL-1β (upper panel), IL-6 (middle panel), and."— Presentation transcript:

1 Figure 4. Inhibition of LPS-induced IL-1β and TNFα, but not IL-6, after exercise. Depicted are LPS-induced IL-1β (upper panel), IL-6 (middle panel), and TNFα (lower panel; all mean ± sem) concentrations in blood obtained from six healthy volunteers (five men and one woman) incubated for 6 h before (○) and 20 min after ending exercise (•). The LPS concentrations used are 0 (sal. = saline), 0.3, 3, 30, and 300 ng/mL. By repeated measures analysis, significant decreases in TNFα (P < 0.001) and IL-1β (P < 0.001) were found. IL-6 production was not significantly affected. From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

2 Figure 3. Cell numbers after HC administration, after exercise, and during the circadian rhythm. Left panel, HC administration. Mean levels (±sem) of circulating WBC, granulocytes (Gran.), lymphocytes (Lymph.), and monocytes (Mono.) after placebo (white bars), 20 mg HC (black bars), or 80 mg HC (hatched bars) administration. Granulocytes showed a significant (*, P < 0.05, by ANOVA followed by post-hoc Scheffe’s test) increase after 80 mg HC administration, whereas monocytes showed the opposite. Lymphocytes showed a graded significant decrease after the administration of increasing doses of HC. Total WBC showed the highest numbers after 80 mg HC administration, which was significantly different from that in the 20 mg HC group, but not from that in the placebo group. Middle panel, Exercise. Circulating total WBC, granulocytes (Gran.), lymphocytes (Lymph.), or monocytes (Mono.) before (white bars) or 20 min after ending exercise (black bars) are depicted. No significant differences, as determined by paired t tests, were detected. Right panel, Circadian rhythm. Circulating WBC, granulocytes (Gran.), lymphocytes (Lymph.), or monocytes (Mono.) in the morning (0800–0830 h; white bars) and in the evening (2000–2030 h; black bars). A significantly (*, P < 0.05, by paired t test) lower amount of lymphocytes was found in the morning (upper level); no other significant differences were noted. From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

3 Figure 1. Plasma cortisol levels after HC administration, after exercise, and during the circadian rhythm. Left panel, HC administration. After HC administration in the morning (0800–0830 h), blood was collected between 1600–1730 h. A significant (P < 0.05) increase in plasma cortisol was only seen in the 80 mg HC group. Middle panel, Exercise. A significant increase in plasma cortisol was seen (P < 0.005) 20 min after ending exercise (after) compared to preexercise levels (before). Right panel, Circadian rhythm. Blood was collected from six men in the morning (0800–0830 h) and in the evening of the same day (2000–2030 h). Plasma cortisol concentrations were significantly lower in the evening then in the morning (P < 0.05). Depicted are the mean and sem. From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

4 Figure 2. Effect of HC administration on LPS-induced IL-1β, IL-6, and TNFα production. Depicted are LPS-induced IL-1β (upper panel), IL-6 (middle panel), and TNFα (lower panel; all mean ± sem) concentrations in blood incubated for 6 h, after the subjects received a placebo (○), 20 mg HC (•), or 80 mg HC (▪). LPS concentrations varied from 0 (sal. = saline) to 300 ng/mL. Blood was collected in the afternoon (1600–1630 h) from seven healthy individuals (three men and four women) after they took HC/placebo in the morning (0800–0830 h). Using repeated measurements, 80 mg HC administration decreased the levels of all three cytokines significantly (P < 0.05). Twenty milligrams of HC decreased ex vivo TNFα production significantly (P = 0.012), but not that of IL-1β or IL-6. From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

5 Figure 5. Influence of circadian rhythm on LPS-induced IL-1β, IL-6, and TNFα production. Blood was collected from six men in the morning (○; 0800–0830 h) or in the evening of the same day (•; 2000–2030 h). LPS-induced dose-dependent increases in IL-1β (upper panel), IL-6 (middle panel), and TNFα (lower panel) production, as measured 6 h after starting the incubation. The LPS concentrations used were 0 (sal.= saline), 1, 3, 10, 30, and 100 ng/mL. Only the TNFα curves showed significant differences, as determined by repeated measures analysis (P = 0.013). From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

6 Figure 6. Dex inhibition of LPS-stimulated IL-1β, IL-6, and TNFα production in vitro. Depicted are LPS (30 ng/mL)-induced IL-1β (upper panel), IL-6 (middle panel), and TNFα (lower panel; all mean ± sem) concentrations in blood incubated for 6 h with different doses of Dex, increasing from 10<sup>−8</sup>-10<sup>−5</sup> mol/L, or without Dex (sal. = saline). Blood was obtained in the morning (○) or in the evening (•). IL-1β showed the highest sensitivity for Dex, being significantly different from TNFα and IL-6, whereas IL-6 was approximately 10–20 times less sensitive than IL-1β or TNFα. Indicated are the mean ± sem. From: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6 J Clin Endocrinol Metab. 1997;82(7): doi: /jcem J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

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