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m-TOR inhibitors: What role in liver transplantation?

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Presentation on theme: "m-TOR inhibitors: What role in liver transplantation?"— Presentation transcript:

1 m-TOR inhibitors: What role in liver transplantation?
Toshiyasu Kawahara, Sonal Asthana, Norman M. Kneteman  Journal of Hepatology  Volume 55, Issue 6, Pages (December 2011) DOI: /j.jhep Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 Structures of sirolimus and everolimus.
Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 An overview of the m-TOR signaling pathway and relative activities. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

4 Fig. 3 Glomerular filtration rate (GFR) either with everolimus or cyclosporine A after liver transplantation. Significantly improved GFR was observed in the everolimus group from 1month after liver transplantation with early withdrawal of cyclosporine A. [28]. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

5 Fig. 4 Creatinine clearance with everolimus or cyclosporine A after liver transplantation. Stable, but not improved renal function was observed after conversion from a calcineurin inhibitor to everolimus a relatively long mean time post-liver transplant (>3years) [29]. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions


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