1. Figure 1. A B C D E F Survival proability (%) Bone marrow blast count20 40 60 80
100
Time since sample collection (years) 1 2 3 5 4 6 7 8
high
intermediate
low
5.0
5.5
6.0
6.5
7.0
7.5
8.0
Control
<5%
5-10%
11-20%
Bone marrow blast count
Proliferation signature score C D
CDKN1C (log2 expression levels)
Proliferation signature score
MKI67 (log2 expression levels)
CDKN1C (log2 expression levels) E F
CDKN1C (log2 expression levels) 2 4 6 8 10
Control
<5%
5-10%
11-20%
Bone marrow blast count
Time since sample collection (years) 1 2 3 4 5 6 7 8 20 40 60 80
100
Survival probability (%)
CDKN1C expression level
intermediate
low
high

2. Figure 2. A B * C D E F * CD34+Ki67+ (%) CD34+KI67+ (%) 3 2 1 CD34+10 20 30 40 50 60
control
< 5%
5-10%
11-20%
CD34+Ki67+ (%) *
Bone marrow blast count C D
Relative CDKN1C
expression
CD34+ 1
P = 0.02
CD34- #1 #2 #3
CDKN1C
β-actin
CD34 + - 10 20 30 40 50
CD34-
CD38high
CDKN1C transcripts
CD34+
CD38low E F 10 20 30 40 50 60
CD34+KI67+ (%)
CDKN1C
positive
negative *

3. Figure 3. A B C Survival probability (%) P = 0.30 P = 0.002 P = 0.401 2 3 4 5 6 7 8 9 10 11 12 13
Time since sample collection (years) 20 40 60 80
100
Survival probability (%)
P = 0.30
CDKN1C status
positive
negative
P = 0.002
P = 0.40 A B C

4. A B Figure 4. Survival probability (%) P = 0.08 P = 0.0081 2 3 4 5 6 7 8 9 10 11 12 13
Time since sample collection (years) 20 40 60 80
100
Survival probability (%)
CDKN1C status
positive
negative
P = 0.08 A
P = 0.008 B