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Volume 114, Issue 3, Pages (March 1998)

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Presentation on theme: "Volume 114, Issue 3, Pages (March 1998)"— Presentation transcript:

1 Volume 114, Issue 3, Pages 462-470 (March 1998)
Dimeric sialyl-Lex expression in gastric carcinoma correlates with venous invasion and poor outcome  Margarida Amado, Fátima Carneiro, Mário Seixas, Henrik Clausen, Manuel Sobrinho–Simões  Gastroenterology  Volume 114, Issue 3, Pages (March 1998) DOI: /S (98) Copyright © 1998 American Gastroenterological Association Terms and Conditions

2 Fig. 1 A case of glandular (intestinal) carcinoma showing S-Lex expression at the cell membrane (arrow) and, to a lesser degree, in the cytoplasm of neoplastic cells (arrowhead) (original magnification 620×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

3 Fig. 2 In this case of isolated cell (diffuse) carcinoma, one can see a focus of neoplastic cells expressing S-Lex in the cytoplasm, adjacent to a focus of nonimmunoreactive cells (original magnification 310×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

4 Fig. 3 High expression of dimeric S-Lex (A) in neoplastic cells within a blood vessel and (B) in a metastatic focus in the liver (original magnification: A, 62×; and B, 155×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

5 Fig. 3 High expression of dimeric S-Lex (A) in neoplastic cells within a blood vessel and (B) in a metastatic focus in the liver (original magnification: A, 62×; and B, 155×). Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

6 Fig. 4 Survival curves of 91 patients with gastric carcinoma (excluding postoperative deaths) according to S-Lex expression. ●, Negative; ▩, low expression; ■, high expression. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

7 Fig. 5 Survival curves of 60 patients with gastric carcinomas in stages II and III (excluding postoperative deaths) according to S-Lex expression. ●, Negative; ▩, low expression, ■, high expression. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions


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