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Volume 121, Issue 4, Pages (April 2002)

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Presentation on theme: "Volume 121, Issue 4, Pages (April 2002)"— Presentation transcript:

1 Volume 121, Issue 4, Pages 1042-1050 (April 2002)
Response of Lung Volumes to Inhaled Salbutamol in a Large Population of Patients With Severe Hyperinflation  Marcus F. Newton, MD, Denis E. O'Donnell, MD, FCCP, Lutz Forkert, MD, FCCP  CHEST  Volume 121, Issue 4, Pages (April 2002) DOI: /chest Copyright © 2002 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Baseline pulmonary function parameters for the NH group, the MH group, and the SH group. Data are expressed as the mean ± SEM. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Changes occurring after bronchodilator administration. Top: the absolute change in values for the SH group, the MH group, and the NH group. Bottom: the percentage change from baseline values. Data are expressed as the mean ± SEM. Changes in absolute terms (L) and relative terms (%) are highly significant for the SH and MH groups (p < 0.001) but are not significant for the NH group. Differences in the changes between the SH and MH groups are indicated by symbols over the SH group bars. Levels of significance: * = p < 0.001; + = p < 0.005; ○ = p < 0.05. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Response patterns for SH patients. See text for explanation of flow and volume responses. Patients who experience a significant increase in both FEV1 and IC are classified as having a combined response, and those who do not experience an increase in either parameter are termed as having no response. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Response patterns for SH patients. See text for explanation of flow and volume responses. See legend of Figure 3 for explanation of combined response and no response. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Response patterns for SH patients. See text for explanation of flow and volume responses. See legend of Figure 3 for explanation of no response. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Comparison of bronchodilator changes according to volume response. The relative change in functional parameters with bronchodilator administration is shown for the three types of volume responses. Using only IC is represented by open bars, the combination of IC plus RV is indicated by shaded hatched bars, and FVC only is indicated by solid bars. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions


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