1. Volume 129, Issue 3, Pages 509-517 (March 2006)
Effects of Tiotropium With and Without Formoterol on Airflow Obstruction and Resting Hyperinflation in Patients With COPD 
van Noord Jan A. , MD, PhD, FCCP, Aumann Joseph L. , MD, Janssens Eduard , MD, Verhaert Jan , MD, Smeets Joseph J. , PhD, Mueller Achim , PhD, Cornelissen Piet J.G. , PhD 
CHEST 
Volume 129, Issue 3, Pages (March 2006)
DOI: /chest
Copyright © 2006 The American College of Chest Physicians Terms and Conditions

2. Figure 1
Study design. *There was no wash-out period between each crossover treatment phase. TIO = tiotropium; PLA = placebo; FORM = formoterol; Labs = laboratory tests.
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Copyright © 2006 The American College of Chest Physicians Terms and Conditions

3. Figure 2
Mean FEV1 before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd.
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Copyright © 2006 The American College of Chest Physicians Terms and Conditions

4. Figure 3
Mean FVC before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd.
CHEST  , DOI: ( /chest )
Copyright © 2006 The American College of Chest Physicians Terms and Conditions

5. Figure 4
Mean IC before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd.
CHEST  , DOI: ( /chest )
Copyright © 2006 The American College of Chest Physicians Terms and Conditions

6. Figure 5
Mean 2-weekly number of puffs of rescue salbutamol per day. NS = not significant.
CHEST  , DOI: ( /chest )
Copyright © 2006 The American College of Chest Physicians Terms and Conditions