Presentation is loading. Please wait.

Presentation is loading. Please wait.

Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy  Mark W. McDonald, MD, Okechukwu R. Linton,

Published byJonah Lewis Modified over 5 years ago

Similar presentations

Presentation on theme: "Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy  Mark W. McDonald, MD, Okechukwu R. Linton,"— Presentation transcript:

1 Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy  Mark W. McDonald, MD, Okechukwu R. Linton, MD, MBA, Cynthia S.J. Calley, MA  International Journal of Radiation Oncology • Biology • Physics  Volume 91, Issue 2, Pages (February 2015) DOI: /j.ijrobp Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Fig. 1 An example of radiation necrosis in a patient treated for a clival chordoma. The left panel shows the presenting magnetic resonance imaging (MRI) with a clival and suprasellar T2 hyperintense tumor with bilateral cavernous sinus involvement and significant brainstem compression. The middle 2 panels show an axial and coronal image of the foci of asymptomatic radiation necrosis that developed in the left temporal lobe. MRI perfusion and spectroscopy were supportive of a diagnosis of radiation necrosis. Encephalomacia is noted in the right temporal lobe from prior surgery. The right panel shows the prior radiation dose superimposed on the MRI demonstrating radiation necrosis, which is transected by the prior 95% isodose line of therapy. Of note, based on its location at the time of treatment planning MRI, the maximum surface dose to the brainstem was 63 Gy (relative biological effectiveness). The patient remains without evidence of recurrent disease 3 years after radiation therapy. After initiation of pentoxifylline and Vitamin E, the area resolved on follow-up MRI. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Fig. 2 Mean dose–volume histogram for temporal lobes with and without radiation necrosis (any grade). The 95% confidence intervals for the mean of each curve are shown by the dashed lines. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2015 Elsevier Inc. Terms and Conditions

4 Fig. 3 Median effective concentration volume risk analysis for temporal lobe radiation necrosis (any grade). Each curve is labeled for the absolute volume of temporal lobe exposed to a dose level in Gy (relative biological effectiveness). International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2015 Elsevier Inc. Terms and Conditions

5 Fig. 4 Absolute dose–absolute volume histogram curve predicted to have a 15% risk of any grade temporal lobe radiation necrosis. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2015 Elsevier Inc. Terms and Conditions

6 Fig. 5 Semilog graph of the correlation between the absolute volume (aV) of temporal lobe receiving 40 Gy (y axis) and 70 Gy (x axis) for temporal lobes with and without subsequent development of any-grade radiation necrosis. Spearman rank-order correlation coefficient between aV40 and aV70 was 0.82, P<.01. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2015 Elsevier Inc. Terms and Conditions

Download ppt "Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy  Mark W. McDonald, MD, Okechukwu R. Linton,"

Similar presentations

A Quantitative Analysis of the Relationship Between Radiation Therapy Use and Travel Time Emma Liu, MM, Pablo Santibáñez, MM, Martin L. Puterman, PhD,

A Quantitative Analysis of the Relationship Between Radiation Therapy Use and Travel Time Emma Liu, MM, Pablo Santibáñez, MM, Martin L. Puterman, PhD,
125I reimplantation in patients with poor initial dosimetry after prostate brachytherapy  Mira Keyes, MD, Tom Pickles, MD, Alexander Agranovich, MD, Winkle.

125I reimplantation in patients with poor initial dosimetry after prostate brachytherapy  Mira Keyes, MD, Tom Pickles, MD, Alexander Agranovich, MD, Winkle.
Incidence of Late Rectal and Urinary Toxicities After Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate.

Incidence of Late Rectal and Urinary Toxicities After Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate.
Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review  David.

Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review  David.
Glucose Metabolism Gene Expression Patterns and Tumor Uptake of 18F- Fluorodeoxyglucose After Radiation Treatment  George D. Wilson, PhD, Bryan J. Thibodeau,

Glucose Metabolism Gene Expression Patterns and Tumor Uptake of 18F- Fluorodeoxyglucose After Radiation Treatment  George D. Wilson, PhD, Bryan J. Thibodeau,
COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results.

COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results.
Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer  Nadya Shusharina, PhD,

Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer  Nadya Shusharina, PhD,
The Case for Prostate Brachytherapy in the Affordable Care Act Era

The Case for Prostate Brachytherapy in the Affordable Care Act Era
Benjamin D. Rosenbluth, M. D. , Victoria Serrano, B. S

Benjamin D. Rosenbluth, M. D. , Victoria Serrano, B. S
Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis  Dot Lowell,

Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis  Dot Lowell,
Late magnetic resonance imaging features of leukoencephalopathy in children with central nervous system tumours following high-dose methotrexate and neuraxis.

Late magnetic resonance imaging features of leukoencephalopathy in children with central nervous system tumours following high-dose methotrexate and neuraxis.
The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation.

The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation.
Toward Magnetic Resonance–Only Simulation: Segmentation of Bone in MR for Radiation Therapy Verification of the Head  Huan Yu, PhD, Curtis Caldwell, PhD,

Toward Magnetic Resonance–Only Simulation: Segmentation of Bone in MR for Radiation Therapy Verification of the Head  Huan Yu, PhD, Curtis Caldwell, PhD,
Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation.

Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation.
Validation of Heat Shock Protein 70 as a Tumor-Specific Biomarker for Monitoring the Outcome of Radiation Therapy in Tumor Mouse Models  Christine Bayer,

Validation of Heat Shock Protein 70 as a Tumor-Specific Biomarker for Monitoring the Outcome of Radiation Therapy in Tumor Mouse Models  Christine Bayer,
The Use of Hormone Therapy Alone Versus Hormone Therapy and Radiation Therapy for Breast Cancer in Elderly Women: A Population-Based Study  Alan M. Nichol,

The Use of Hormone Therapy Alone Versus Hormone Therapy and Radiation Therapy for Breast Cancer in Elderly Women: A Population-Based Study  Alan M. Nichol,
Cost-Effectiveness Analysis of Stereotactic Body Radiotherapy and Radiofrequency Ablation for Medically Inoperable, Early-Stage Non–Small Cell Lung Cancer 

Cost-Effectiveness Analysis of Stereotactic Body Radiotherapy and Radiofrequency Ablation for Medically Inoperable, Early-Stage Non–Small Cell Lung Cancer 
Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From.

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From.
18Fluorodeoxyglucose PET Is Prognostic of Progression-Free and Overall Survival in Locally Advanced Pancreas Cancer Treated With Stereotactic Radiotherapy 

18Fluorodeoxyglucose PET Is Prognostic of Progression-Free and Overall Survival in Locally Advanced Pancreas Cancer Treated With Stereotactic Radiotherapy 
Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation.

Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation.

Similar presentations

Ads by Google