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Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis  Dot Lowell,

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Presentation on theme: "Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis  Dot Lowell,"— Presentation transcript:

1 Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis  Dot Lowell, M.D., Stephen B. Tatter, M.D., Ph.D., J. Daniel Bourland, Ph.D., Allan F. deGuzman, Ph.D., Kenneth E. Ekstrand, Ph.D., Thomas L. Ellis, M.D., James F. Lovato, M.S., Kevin P. McMullen, M.D., Michael T. Munley, Ph.D., Edward G. Shaw, M.D., M.A., James J. Urbanic, M.D., Michael D. Chan, M.D.  International Journal of Radiation Oncology • Biology • Physics  Volume 81, Issue 4, Pages e519-e524 (November 2011) DOI: /j.ijrobp Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Fig. 1 (A) Axial T1-weighted spoiled gradient echo MRI used for treatment planning for Gamma Knife radiosurgery for an acoustic neuroma. Prescription dose of 11.5 Gy was delivered to the 45% isodose line and tumor margin. (B) Axial T1-weighted spoiled gradient echo MRI acquired at time of the same patient developing symptomatic noncommunicating hydrocephalus. This image reveals a treatment response with development of central hypoattenuation within the tumor. International Journal of Radiation Oncology • Biology • Physics  , e519-e524DOI: ( /j.ijrobp ) Copyright © 2011 Elsevier Inc. Terms and Conditions

3 Fig. 2 (A) Axial T1-weighted spoiled gradient echo MRI used for treatment planning for Gamma Knife radiosurgery (GKRS) for a facial nerve schwannoma. Prescription dose of 12 Gy was delivered to the 50% isodose line and tumor margin. The patient developed a facial nerve palsy 1 week after GKRS. (B) Axial T1-weighted spoiled gradient echo MRI acquired 16 months after GKRS, showing a central hypoattenuation within the tumor. International Journal of Radiation Oncology • Biology • Physics  , e519-e524DOI: ( /j.ijrobp ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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