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Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized, controlled study.

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Presentation on theme: "Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized, controlled study."— Presentation transcript:

1 Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction  Akshay S. Desai, MD, MPH, Eldrin F. Lewis, MD, MPH, Rebecca Li, PhD, Scott D. Solomon, MD, Susan F. Assmann, PhD, Robin Boineau, MD, Nadine Clausell, MD, Rafael Diaz, MD, Jerome L. Fleg, MD, Ivan Gordeev, MD, Sonja McKinlay, PhD, Eileen O'Meara, MD, Tamaz Shaburishvili, MD, Bertram Pitt, MD, Marc A. Pfeffer, MD, PhD  American Heart Journal  Volume 162, Issue 6, Pages e10 (December 2011) DOI: /j.ahj Copyright © 2011 Mosby, Inc. Terms and Conditions

2 Figure 1 The TOPCAT schema and study visit schedule. QOL indicates quality of life; ECHO, echocardiography. American Heart Journal  , e10DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

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