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Quality of life and chronic heart failure therapy guided by natriuretic peptides: Results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy.

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Presentation on theme: "Quality of life and chronic heart failure therapy guided by natriuretic peptides: Results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy."— Presentation transcript:

1 Quality of life and chronic heart failure therapy guided by natriuretic peptides: Results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study  Anju Bhardwaj, MD, Shafiq U. Rehman, MD, Asim A. Mohammed, MD, Hanna K. Gaggin, MD, MPH, Linda Barajas, RN, Justine Barajas, Stephanie A. Moore, MD, Dorothy Sullivan, NP, James L. Januzzi, MD  American Heart Journal  Volume 164, Issue 5, Pages e1 (November 2012) DOI: /j.ahj Copyright © 2012 Mosby, Inc. Terms and Conditions

2 Figure 1 Quality of life scores at each visit for each treatment group. At baseline, overall Minnesota Living with Heart Failure Questionnaire scores were comparable between SOC and NT-proBNP guided arms. While both groups showed improved quality of life, overall scores improved more in the NT-proBNP study arm. American Heart Journal  , e1DOI: ( /j.ahj ) Copyright © 2012 Mosby, Inc. Terms and Conditions

3 Figure 2 Correlation between relative change in Minnesota Living with Heart failure questionnaire score and relative change in NT-proBNP concentrations. A significant correlation exists after study procedures; a cubic fit line is displayed. American Heart Journal  , e1DOI: ( /j.ahj ) Copyright © 2012 Mosby, Inc. Terms and Conditions

4 Figure 3 Event rates as a function of Minnesota Living with Heart Failure Questionnaire tertile. Those with the least improvement in their quality of life scores had the highest event rates. American Heart Journal  , e1DOI: ( /j.ahj ) Copyright © 2012 Mosby, Inc. Terms and Conditions

5 Supplemental Figure 1 Improvement in quality of life compared to the change in NT-proBNP levels. The most remarkable improvement was observed in patients with most significant drop in NT-proBNP values, intermediate in patient with no change in NT-proBNP, and least in patients who had a rise in NT-proBNP levels American Heart Journal  , e1DOI: ( /j.ahj ) Copyright © 2012 Mosby, Inc. Terms and Conditions


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