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Morten Hoyer, Ph. D. , Henrik Roed, D. M. Sc

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1 Prospective study on stereotactic radiotherapy of limited-stage non–small-cell lung cancer 
Morten Hoyer, Ph.D., Henrik Roed, D.M.Sc., Anders Traberg Hansen, B.S., Lars Ohlhuis, Jorgen Petersen, B.S., Hanne Nellemann, M.D., Anne Kiil Berthelsen, M.D., Cai Grau, D.M.Sc., Svend Aage Engelholm, D.M.Sc., Hans von der Maase, D.M.Sc.  International Journal of Radiation Oncology • Biology • Physics  Volume 66, Issue 4, Pages S128-S135 (November 2006) DOI: /j.ijrobp Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Fig. 1 Treatment plan for stereotactic body radiotherapy of a patient with non–small-cell lung cancer. International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions

3 Fig. 2 Age, lung physiology according to forced expiratory volume in 1 s (FEV-1), and tumor diameter before treatment in 40 patients with Stage I non–small-cell lung cancer treated with stereotactic body radiotherapy. International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions

4 Fig. 3 Failure pattern in 16 of 40 patients with Stage 1 non–small-cell lung cancer (NSCLC) after stereotactic body radiotherapy, according to local (T), thoracic node (N), or distant failures (M). Two patients with M failure were considered as having possible new primary cancers. International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions

5 Fig. 4 Local control and progression-free survival (a) and cancer-specific and overall survival (b) in 40 patients treated with stereotactic body radiotherapy. International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions

6 Fig. 5 Cancer-specific survival in patients with tumor diameter ≤30 mm or >30 mm (p = 0.04). International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions

7 Fig. 6 Actuarial time course of performance status (a) and lung function (b) in patients treated with stereotactic body radiotherapy. World Health Organization (WHO) performance status 2 is defined as being ambulatory and capable of all self-care but unable to carry out any work activities and in bed less than half of the day. Grade 2 pulmonary toxicity is characterized by dyspnea during exercise. International Journal of Radiation Oncology • Biology • Physics  , S128-S135DOI: ( /j.ijrobp ) Copyright © 2006 Elsevier Inc. Terms and Conditions


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