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Higher-Than-Conventional Radiation Doses in Localized Prostate Cancer Treatment: A Meta-analysis of Randomized, Controlled Trials  Gustavo Arruda Viani,

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Presentation on theme: "Higher-Than-Conventional Radiation Doses in Localized Prostate Cancer Treatment: A Meta-analysis of Randomized, Controlled Trials  Gustavo Arruda Viani,"— Presentation transcript:

1 Higher-Than-Conventional Radiation Doses in Localized Prostate Cancer Treatment: A Meta-analysis of Randomized, Controlled Trials  Gustavo Arruda Viani, M.D., Eduardo Jose Stefano, M.D., Sergio Luis Afonso, M.D.  International Journal of Radiation Oncology • Biology • Physics  Volume 74, Issue 5, Pages (August 2009) DOI: /j.ijrobp Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Fig. 1 Flowchart according to Quality of Reporting of Meta-analyses criteria. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

3 Fig. 2 Meta-analysis regarding biochemical failure for all subgroups. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

4 Fig. 3 Meta-analysis regarding biochemical failure for the low-risk group. CI = confidence interval. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

5 Fig. 4 Meta-analysis regarding biochemical failure for the intermediate-risk group. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

6 Fig. 5 Meta-analysis regarding biochemical failure for the high-risk group. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

7 Fig. 6 Meta-analysis regarding mortality rate. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

8 Fig. 7 Meta-analysis regarding prostate cancer–specific mortality. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

9 Fig. 8 Gastrointestinal toxicity of Grade ≥2 in the trials comparing high-dose radiotherapy with conventional-dose radiotherapy. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

10 Fig. 9 Genitourinary toxicity of Grade ≥2 in the trials comparing comparing high-dose radiotherapy with conventional-dose radiotherapy. CI = confidence interval. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

11 Fig. 10 Meta-regression analysis for biochemical control as a function of the radiotherapy total dose for all subgroups present in six trials. RTTD = radiotherapy total dose. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

12 Fig. 11 Meta-regression analysis for biochemical control as a function of the radiotherapy total dose for the low-risk group present in four trials. RTTD = radiotherapy total dose. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

13 Fig. 12 Meta-regression analysis for biochemical control as a function of the radiotherapy total dose for the intermediate-risk group present in five trials. RTTD = radiotherapy total dose. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

14 Fig. 13 Meta-regression analysis for biochemical control as a function of the radiotherapy total dose for the high-risk group present in five trials. RTTD = radiotherapy total dose. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

15 Fig. 14 Funnel plot to evaluate publication bias.
International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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