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Evaluation of analgesic and sedative effects of continuous infusion of dexmedetomidine by measuring somatosensory- and auditory-evoked potentials in the.

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Presentation on theme: "Evaluation of analgesic and sedative effects of continuous infusion of dexmedetomidine by measuring somatosensory- and auditory-evoked potentials in the."— Presentation transcript:

1 Evaluation of analgesic and sedative effects of continuous infusion of dexmedetomidine by measuring somatosensory- and auditory-evoked potentials in the rat  Naomi D Franken, MSc, Hugo Van Oostrom, MSc, Peter J Stienen, PhD, Arie Doornenbal, Ludo J Hellebrekers, PhD, DVM, Diplomate ECVAA  Veterinary Anaesthesia and Analgesia  Volume 35, Issue 5, Pages (September 2008) DOI: /j x Copyright © 2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

2 Figure 1 Changes in SEP waveforms during CRI of dexmedetomidine. Grand mean (bold lines) and SEM (plain lines) waveforms of the Vx-SEP (a) and SI-SEP (b) during different infusion rates of dexmedetomidine. Curve interruption and dotted vertical lines denote stimulus onset and the latency range (x to m) for which the RDF is calculated, respectively. Peaks are designated by P (positive peak) and N (negative peak) accompanied by their rounded off mean latency (mseconds). Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

3 Figure 2 Changes in AEP waveforms during CRI of dexmedetomidine. Grand mean (bold lines) and SEM (plain lines) waveforms of the Vx-AEP (a) and AI-AEP (b) during different infusion rates of dexmedetomidine. Curve interruption and dotted vertical lines denote stimulus onset and the latency range (x to m) for which the RDF is calculated, respectively. Peaks are designated by P (positive peak) and N (negative peak) accompanied by their rounded off mean latency (mseconds). Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

4 Figure 3 RDF changes by different doses of dexmedetomidine for the Vx-SEP and SI-SEP in the latency range x to m (see Fig. 1). Data are presented as the mean relative RDF (±SEM, n = 9) over five subsequent time-blocks for the four different treatments. Time-block 1, 2 and 3 represent the data during infusion of dexmedetomidine, whereas time-block 4 and 5 represent the data after terminating the CRI. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

5 Figure 4 RDF changes by different doses of dexmedetomidine for the Vx-AEP and AI-AEP in the latency range x to m (see Fig. 2). Data are presented as the mean relative RDF (±SEM, n = 9) over five subsequent time-blocks for the four different treatments. Time-block 1, 2 and 3 represent the data during infusion of dexmedetomidine, whereas time-block 4 and 5 represent the data after terminating the CRI. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions


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