1. Glioblastoma multiforme (GBM)
Glioblastoma multiforme (GBM). A, The right cerebral hemisphere is expanded by an irregularly contoured mass containing areas of necrosis (yellow) and small areas of hemorrhage. Although this lesion appears fairly well demarcated in this gross photograph, GBMs are aggressive astrocytic neoplasms that widely infiltrate the surrounding brain. B, The distinction between the various grades of infiltrating astrocytic neoplasms is based upon four histologic features: nuclear pleomorphism, mitotic figures, endothelial proliferation, and necrosis. GBMs, by definition, contain at least three of these four histologic features. In this section, the necrosis is apparent (star). As is characteristic for GBMs, this tumor has palisading of neoplastic cells at the edge of the necrosis (arrow). Hematoxylin and eosin, 100×.
Source: Chapter 11. Neuropathology, Pathology: The Big Picture
Citation: Kemp WL, Burns DK, Brown TG. Pathology: The Big Picture; 2008 Available at: Accessed: October 19, 2017
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