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Hyaluronic acid stimulates tumor-cell proliferation at wound sites

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Presentation on theme: "Hyaluronic acid stimulates tumor-cell proliferation at wound sites"— Presentation transcript:

1 Hyaluronic acid stimulates tumor-cell proliferation at wound sites
Yoko Matsui, MD, Masafumi Inomata, MD, Koichi Izumi, MD, Kazuya Sonoda, MD, Norio Shiraishi, MD, Seigo Kitano, MD, FACS  Gastrointestinal Endoscopy  Volume 60, Issue 4, Pages (October 2004) DOI: /S (04) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

2 Figure 1 A, Increases in tumor volume over time. B, Tumor weight on day 14 after tumor-cell inoculation. Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

3 Figure 1 A, Increases in tumor volume over time. B, Tumor weight on day 14 after tumor-cell inoculation. Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

4 Figure 2 PCNA-labeling index of tumors in HA and control groups on day 14 after inoculation of tumor cells. Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

5 Figure 3 A, Photomicrograph showing expression of CD44 protein in section of tumor tissue from wound site in HA group mouse (IM7 antibody stain; bar=60 μm). B, Photomicrograph showing nonexpression of CD44 protein in section of tumor tissue from wound site in control group mouse (IM7 antibody stain; bar=60 μm). Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

6 Figure 3 A, Photomicrograph showing expression of CD44 protein in section of tumor tissue from wound site in HA group mouse (IM7 antibody stain; bar=60 μm). B, Photomicrograph showing nonexpression of CD44 protein in section of tumor tissue from wound site in control group mouse (IM7 antibody stain; bar=60 μm). Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

7 Figure 4 A, Immunoblot analysis with specific rat anti-mouse CD44 monoclonal antibody (mAb; clone KM114), showing CD44 expression levels in tumors. B, Two lines on right show CBB stain of each group. Gastrointestinal Endoscopy  , DOI: ( /S (04) ) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions


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