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The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals  Maartje Verschuur, Annemarie.

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Presentation on theme: "The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals  Maartje Verschuur, Annemarie."— Presentation transcript:

1 The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals  Maartje Verschuur, Annemarie Jellema, Else M. Bladbjerg, Edith J. M. Feskens, Ronald P. Mensink, Lars Møller, Hans L. Vos, Moniek P.M. de Maat  Atherosclerosis  Volume 181, Issue 2, Pages (August 2005) DOI: /j.atherosclerosis Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 The promoter region of the PAI-1 gene. The −844A/G and the −675(4G/5G) variations and the locations of the haplotype-specific PCR primers are shown. The bottom part shows the fragments formed after digestion of the PCR products with XhoI. Atherosclerosis  , DOI: ( /j.atherosclerosis ) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 PAI-1 antigen levels of the haplotype combinations in the overall MORGEN sample (A) and in BMI Quartiles of the MORGEN sample (B). Bars represent the geometric mean (±S.D.) of the PAI-1 antigen levels expressed as a percentage of the geometric mean of the overall population, for each haplotype combination separately. Relative geometric means and number of subjects are indicated. Rare haplotype combinations are not shown, their relative PAI-1 antigen levels are: Quartile 2: (A-5G/A-5G: (n=1)), Quartile 3: (A-4G/G-4G: 92.3 (n=1)) and (G-4G/G-5G: (±55.7) (n=2)), Quartile 4: (G-4G/G-4G: (n=1)) and (A-5G/A-5G: (n=1)). Atherosclerosis  , DOI: ( /j.atherosclerosis ) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 PAI-1 antigen levels of the haplotype combinations in the overall Glostrup population (A) and in BMI Quartiles of the Glostrup population (B). Bars represent the geometric mean (±S.D.) of the PAI-1 antigen levels expressed as a percentage of the geometric mean of the overall population, for each haplotype combination separately. Relative geometric means and number of subjects are indicated. Rare haplotype combinations are not shown, their relative PAI-1 antigen levels are: Quartile 1: (A-4G/G-4G: 28.6 (±6.5) (n=2)), Quartile 3: (A-4G/G-4G: 82.3 (±18.1) (n=3)) and (A-5G/A-5G: (n=1)), Quartile 4: (A-5G/A-5G: (n=1)). Atherosclerosis  , DOI: ( /j.atherosclerosis ) Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions


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