1. From: Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation
Invest. Ophthalmol. Vis. Sci ;55(10): doi: /iovs
Figure Legend:
(A) The dose-response relationship between daily orally dosed pazopanib and the reduction in CNV area is shown. Data points are mean percent inhibition averaged across 3 independent experiments, each of which tested 4 to 6 doses. The ED50 of pazopanib is 63 mg/kg. Error bars indicate ±1 SD. Doses assessed in fewer than 3 studies do not have error bars; experimental details for the 3 studies are given in Supplementary Figures S2 through S4. (B) The mean ± SEM area of CNV from one representative experiment evaluating the inhibition of laser-induced CNV of mice orally dosed with vehicle, pazopanib, or a positive control, BFH772 (a LMW VEGF receptor inhibitor). The number above each bar is the percentage of inhibition relative to the average CNV area in vehicle-treated mice. For doses ≥30 mg/kg, differences in CNV area are significantly different from those of vehicle-treated mice (****P < by ANOVA with Dunnett's post hoc analysis). (C–F) Representative fluorescent images are shown of CNV 7 days after laser treatment of mice dosed daily with vehicle, pazopanib, or BFH772. (C) Vehicle; (D) 30 mg/kg pazopanib; (E) 300 mg/kg pazopanib; (F) 3 mg/kg BFH772. Lesions are outlined by analysis software (see Methods). Scale bars: 100 μm.
Date of download: 10/3/2017
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