1. Main Figures and Tables

2. Figure 1
Strategy (shall we make a strategy figure here??）

3. Need to replaced by the final figures
samples a b
proteins
a) Sample-sample correlation plot using all the quantified kinases; b) clustering analysis of samples based on the differential expressed kinase; C) Supervised cluster analysis
ZW: we can cut the samples labels
control
cancer
Need to replaced by the final figures
high
low

4. Figure 3.
Signaling pathway analysis of the differential proteins
(pathway will be generated either by IPA or KEGG)

5. Table 1.
Descriptive characteristics of the patients with NSCLC

6. Figure 4.

7. Figure 5.
DAPK2
MELK
MELK in Adenocacinoma
MELK in Squamouse cell carcinoma

8. Table 2. Correlation analysis

9. Supplementary Figures

10. Supplementary Figure S1 – PCA AnalysisB C
cancer
cancer
control
proteins
control
PCA on samples with p<0.05
PCA on samples without any filter
PCA on proteins with p<0.05

11. Squamouse cell carcinoma
Supplementary Figure S2
EGFR
Adenocarcinoma
Squamouse cell carcinoma
P = 0,006231
P = 0,03599
high expression
Overall Survival Probability
low expression
Overall Survival [months]

12. Adenocarcinoma & Squamouse cell carcinoma
Supplementary Figure S3
DAPK2 a.
Adenocarcinoma & Squamouse cell carcinoma
P = 0,008825
low expression (n=45)
high expression (n=275)
Overall Survival Probability
Overall Survival [months]

13. Squamouse cell carcinoma
DAPK2 b. c.
Adenocarcinoma
Squamouse cell carcinoma
low expression (n=33)
Overall Survival Probability
low expression (n=12)
P = 0,0198
high expression (n=113)
P = 0,03282
high expression (n=162)
Overall Survival [months]
Overall Survival [months]

14. Adenocarcinoma & Squamouse cell carcinoma
Supplementary Figure S4
MELK a.
Adenocarcinoma & Squamouse cell carcinoma
P = 0,043
low expression (n=68)
high expression (n=291)
Overall Survival Probability
Overall Survival [months]

15. Squamouse cell carcinoma
MELK b. c.
Adenocarcinoma
Squamouse cell carcinoma
Overall Survival Probability
low expression (n=28)
low expression (n=40)
P = 0,69
P = 0,017
high expression (n=153)
high expression (n=139)
Overall Survival [months]
Overall Survival [months]
Overall Survival [months]

16. Squamouse cell carcinoma
DDR1 b. c.
Adenocarcinoma
Squamouse cell carcinoma
high expression (n=20)
Overall Survival Probability
high expression (n=54)
low expression (n=29)
P = 0,0485
P = 0,7228
moderate expression (n=100)
low expression (n=157)
Overall Survival [months]
Overall Survival [months]
Overall Survival [months]
Overall Survival [months]