1. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis JAMA Intern Med. 2014;174(11):1755-1762. doi:10.1001/jamainternmed.2014.4056 Flow Diagram Search and selection process used for studies included in the systematic review. Figure Legend:

2. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis JAMA Intern Med. 2014;174(11):1755-1762. doi:10.1001/jamainternmed.2014.4056 Funnel Plot of Rebleeding Within 7 Days From Individual Studies in the Meta-analysisSE indicates standard error. Figure Legend:

3. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis JAMA Intern Med. 2014;174(11):1755-1762. doi:10.1001/jamainternmed.2014.4056 Forest Plot of Studies Comparing Intermittent With Bolus Plus Continuous-Infusion Proton Pump Inhibitors in Patients With High- Risk Bleeding UlcersThe outcome examined was rebleeding within 7 days in the intention-to-treat population. M-H indicates Mantel- Haenszel. Figure Legend: