1. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Schematic median sagittal cut of the human brain displaying CSF circulation. Arrows indicate flow direction. L: lateral ventricles, Mo: foramen of Monro, III: third ventricle, Aq: aqueduct of Sylvius, IV: fourth ventricle, A: arachnoid villi, C: cerebellomedullary cistern, ChP: choroid plexus of lateral ventricles, S: superior sagittal sinus. (Based on: Putz/Pabst: Sobotta, Atlas der Anatomie des Menschen, 21th ed. 2000, © Elsevier, Urban & Fischer München. Used with permission). Figure Legend:

2. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Schematic of a general single compartment model Figure Legend:

3. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Rendering of a ventricular system segmented from in vivo MRI data. Data provided by Dr. P. Summers, Institute of Neuroradiology, University Hospital Zurich. Figure Legend:

4. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Aqueduct of Sylvius, center section. Left: normal aqueduct. Right: stenosed aqueduct with a 25% smaller cross-sectional area half way between the third and fourth ventricle. Figure Legend:

5. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Pressure variation in the lateral ventricles in dependence of the third ventricle displacement and velocity. The graphs apply to both the ventricular system with and without aqueduct stenosis. Figure Legend:

6. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Average pressure in the lateral ventricles over the course of one cycle, both in cases with and without aqueduct stenosis. Figure Legend:

7. Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System J Biomech Eng. 2004;127(2):264-269. doi:10.1115/1.1865191 Maximum axial velocity in the aqueduct of Sylvius midway between the third and fourth ventricle. One cycle for both the stenosed and the regular system is depicted. Figure Legend: