1. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo Reflectance Confocal Microscopy Arch Dermatol. 2010;146(5):492-498. doi:10.1001/archdermatol.2009.388 Study group lesion. A, In vivo reflectance confocal microscopy of dermal bright cells in a lichen planus–like keratosis. Dermal bright cells seen (melanophages) are typically small, with ill-defined edges and no visible nuclei (hyporeflective ovoid to round bodies) visible. However, some cells (arrows) contained very small nuclei. Bar indicates 50 μm. B, Histopathologic findings of small melanophages (arrows) and scattered lymphocytes in the superficial dermis (original magnification ×400). Figure Legend:

2. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo Reflectance Confocal Microscopy Arch Dermatol. 2010;146(5):492-498. doi:10.1001/archdermatol.2009.388 Study group lesion. A, In vivo reflectance confocal microscopy of dense ill-defined aggregates of dermal bright cells in a lichen planus–like keratosis. Melanophages aggregate when they are particularly numerous in the upper dermis. These aggregates (arrows) are different from the nests typically observed in melanocytic lesions because the edges of the melanophage aggregates are ill defined, and few nuclei are seen. Bar indicates 50 μm. B, Histopathologic findings of melanophage aggregates in the superficial dermis (arrow) (original magnification ×400). Figure Legend:

3. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo Reflectance Confocal Microscopy Arch Dermatol. 2010;146(5):492-498. doi:10.1001/archdermatol.2009.388 Control group 1 lesion. A, In vivo reflectance confocal microscopy of dermal bright cells in a dysplastic compound nevus. Dermal bright nevus cells are typically larger than melanophages, round, and well defined, with larger-diameter visible nuclei (arrows). Bar indicates 50 μm. B, Histopathologic findings of large nevus cells involving the junctional zone of the epidermis (cells with pale cytoplasm marked by arrows) and nevus cells in the dermis (original magnification ×200). Figure Legend:

4. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo Reflectance Confocal Microscopy Arch Dermatol. 2010;146(5):492-498. doi:10.1001/archdermatol.2009.388 Control group 3 lesion. A, In vivo reflectance confocal microscopy (RCM) of dermal bright cells in an inflammatory skin lesion. These dermal bright cells are smaller than melanophages, with nonvisible nuclei (arrows). Bar indicates 50 μm. B, Histopathologic findings of epidermal spongiosis, focal interface inflammation with lichenoid change, and mixed dermal inflammatory cell infiltrate consisting predominantly of small lymphocytes (note the paucity of melanophages in the dermal inflammatory cell infiltrate corresponding to the RCM image) (original magnification ×400). Figure Legend:

5. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Morphologic Features of Melanophages Under In Vivo Reflectance Confocal Microscopy Arch Dermatol. 2010;146(5):492-498. doi:10.1001/archdermatol.2009.388 Control group 1 lesion. A, In vivo reflectance confocal microscopy of dermal bright cells in an advanced lentigo maligna. Dermal bright melanoma cells are typically larger than melanophages, round, and well defined, with large diameter and visible nuclei (arrows); some are organized in dense nests (short arrows). The dermoepidermal junction is destroyed, so the distinction between dermal and epidermal bright cells is unclear. Bar indicates 50 μm. B, Histopathologic findings of large atypical melanocytes (arrows) involving the basal region of the epidermis and the edge of a pilosebaceous unit (original magnification ×400). Figure Legend: