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Skin Pathology, Case 3 40 year-old female with no significant past medical history presents with a 1 cm pigmented lesion on the back. The borders are irregular.

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Presentation on theme: "Skin Pathology, Case 3 40 year-old female with no significant past medical history presents with a 1 cm pigmented lesion on the back. The borders are irregular."— Presentation transcript:

1 Skin Pathology, Case 3 40 year-old female with no significant past medical history presents with a 1 cm pigmented lesion on the back. The borders are irregular and the color is variegated.

2 Describe the skin lesion

3 The "ABCDs" are helpful in the diagnosis of melanoma. A: asymmetry- one side or half does not look like the other B: border irregularity C: color-black, or much darker than patient's other moles D: diameter > 6 millimeters

4 Close up Describe the skin lesion

5 Close up This melanoma is darker than any of the other pigmented lesions present. On close-up the lesion is seen to have an irregular border and also has uneven coloration with some darker areas.

6 Describe the skin lesion

7 This darkly pimented lesion was suspected of being a melanoma. It is shown undergoing excisional biopsy. When feasible, the entire lesion should be removed and submitted for histopathological diagnosis. This melanoma had a thickness of 0.6 mm. The patient was later treated with a wide local excision.

8 Describe the skin lesion

9 The lesion (melanoma) is asymmetrical, has an irregular border, very dark and irregular color, and was much larger than 6 mm in diameter.

10 Describe the skin lesion

11 Nodular melanoma. This lesion demonstrates all of the ABCDs.

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13 Epidermis with focal ulceration Nests of malignant melanocytes within dermis

14 Describe the high power findings

15 Clusters of malignant melanoma cells (in dermis) Pigmented melanoma cells

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17 Irregular nests of malignant melanoma cells within epidermis Nodular aggregates of melanoma cells in dermis

18 Irregular nests of malignant melanocytes in epidermis


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