1. Part 1 : Modern analytical chemistry

2. Analytical techniques Qualitative analysis: the detection of the presence but not the quantity of a substance in a mixture, for example, forbidden substances in an athlete’s blood. Quantitative analysis: the measurement of the quantity of a particular substance in a mixture, for example, the alcohol levels in a driver’s breath, or the toxic metal levels in a sample of river water. Structural analysis: a description of how atoms are arranged in molecular structures, for example, the determination of the structure of a naturally occurring or artificial product.

3. Methods studied this year Infrared spectroscopy which is used to identify the bonds in a molecule. Nuclear magnetic resonance spectroscopy which is used to show the chemical environment of certain atoms (hydrogen, carbon, phosphorus and fluorine) in a molecule and so gives vital structural information.

4. Example 1

5. Example 2

6. Example 3

7. The electromagnetic spectrum

8. Wavelength (λ) : the distance between two successive crests or troughs (in m) Frenquency (ν): the number of waves which pass a point every second (in Hz)

9. Absorption and emission spectra

10. Number of carbon atoms in the longest chainstem 1Meth- 2Eth- 3Prop- 4But- 5Pent- 6Hex- 7Hept- 8Oct- 9Non- 10Dec- Nomenclature of organic compounds

11. Functional groups

12. Substituent group

13. Ester functional group

14. Infrared (IR) spectroscopy Whatever the state of a molecule, the atoms are not fixed (or motionless), their bonds vibrate or bend. Therefore, a chemical bond can be thought as a spring.

15. IR spectroscopy IR spectroscopy is the study of absorption of organic species for radiations between 800 and 1000 nm. The infrared spectrum of a species is shown in a graph of the transmittance T (in %) against the wavenumber σ (in cm -1 ). In IR spectroscopy, the frequency of radiation is often measured as number of waves per centimetre (cm -1 ), also called the wavenumber. The spectrum shows bands of absorption : as the vibration of a bond is excited, the molecule absorbs the radiation and therefore the transmittance falls, producing a peak or a band of absorption.

16. Matching wavenumbers with bonds

18. Different parts of an IR spectrum From 4000 to 1400 cm -1 the spectrum shows the characteristic bands or peaks of the bonds. From 1400 to 500 cm -1, this part, more complex, is typical of the compound and is often named as the « fingerprint » of the molecule.

19. Structure of propanone

20. Identification of an organic compound The formula of an organic molecule M is C 4 H 8 O. We know that the molecule is not a cyclic one. Which are the possible functional groups corresponding to the presence of one oxygen atom in the M molecule? Prove the presence of a double bond in the molecule, either between two carbon atoms or between one carbon atom and one oxygen atom. Justify using the octet rule.

21. The IR spectrum of the molecule is shown below: Which extra information does this spectrum give us? Write down the structural formulae of the three possible molecules. The molecule comes from the oxidation of a second class alcohol. Conclude.