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The Hot Zone By Richard Preston

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1 The Hot Zone By Richard Preston

2 Part One: The Shadow of Mt. Elgon

3 Mount Elgon Kenya-Uganda Border Ancient inactive volcano--huge caldera

4 Kitum Cave

5 Elephants and Bats

6 Elephant Scrapings

7 Insects And Rock Hyrax

8 USAMRIID United States Army Medical Research Institute on Infectious Disease

9 Chemturion Suit Racal Suit

10 Marburg Filovirus Related to Ebola Originated in Africa
1st Outbreak in Germany Level 4 biocontainment Causes headache, muscle ache, fever, vomiting, hemorrhaging, death

11 UPCOMING GRAPHIC PICTURES
Ebola Filovirus 5 Types Ebola Zaire Ebola Sudan Ebola Reston Ebola Tai Forest 5. Ebola Bundibugyo WARNING: UPCOMING GRAPHIC PICTURES

12

13 Transmission

14 Treatments Working on vaccine Supportive Care Fluids, electrolytes Oxygen Treat other infections Prevention is key Proper hygiene (wash hands!) Avoid contact with bats and primate meat/fluids Avoid travel to infected areas Do not handle Ebola patient’s items

15 Ebola Zaire Most deadly form of Ebola 90% fatality rate
There have been more outbreaks of Ebola-Zaire than any other type of Ebola 1st outbreak was in 1976 in Yambuku, Zaire Index Case—Mabelo Lokela

16 Ebola Sudan Index case—Mr. Yu. G.

17 Ebola Reston You will learn more about this outbreak in the next section

18 Ebola Tai Forest Formally Ebola Ivory Coast
1st outbreak in 1994 (after The Hot Zone was written) Autopsy on a wild chimpanzee Not much is known

19 Ebola Bundibugyo Outbreak occurred in December 2007-January 2008
37 dead, 149 infected in an outbreak in the Bundibugyo district in Western Uganda

20 March 2014 Outbreak The largest outbreak ever in recorded history started in There were 28,639 cases and 11,316 people died Effected multiple countries including Guinea, Sierra Leone and Liberia most heavily As of , no cases in Guinea, Liberia, Sierra Leone Related to Ebola Zaire, type ??

21 Survivors After the 2014 Ebola outbreak there are more Ebola survivors than ever before. Persistent medical conditions--joint pain, eye problems, headaches, and other chronic health issues Ebola virus can stay in certain body fluids

22 Part Two: The Monkey House

23 Reston, Virginia

24 Reston, Virginia

25 Reston Primate Quarantine Unit
Quarantine monkeys for 1 month Sent monkeys all over the U.S. for laboratory research Crab Eating Monkeys—Long Tailed Macaques Island of Mindanao  Manila  Amsterdam  New York  Reston, Virginia

26 Nancy Jaax (USAMRIID)

27 Jerry Jaax (USAMRIID)

28 CJ Peters (USAMRIID)

29 Tom Geisbert (USAMRIID)

30 Peter Jahrling (USAMRIID)

31 Joe McCormick (CDC)

32 Fred Murphy (CDC)

33 The Institute Video


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