1. Translation

9. The enzyme: Amminoacyl-tRNA synthetase

12. Polymerization

13. The factory

14. Figura 8.3 Small subunit Large subunit

34. Regulation of gene expression

35. Regulation of protein stability

36. The proteasome

37. Figure 6-92b Molecular Biology of the Cell (© Garland Science 2008) Polyubiquitination marks proteins that should be degraded

38. Figure 6-92c Molecular Biology of the Cell (© Garland Science 2008)

41. Figure 6-93 Molecular Biology of the Cell (© Garland Science 2008)

42. Regulation of translation

43. 5’ 3’ coding Regulation UTR

45. Regulation of translation by miRNAs

47. Regulation of translation by mTORC1

48. Translation mTORC 1 S6K1 4EBP1 TIF1 A UBF SL1 RNA Pol I transcription rRNA eIF4E tRNA RNA Pol III transcription RNA Pol III transcription 4EBP1 P P MAF1 P inattivo attivo attiva inattiva attiva + + -

52. Protein synthesis