3. 1.National kidney and urologic diseases information clearinghouse: Kidney statistics for the United States 2. United States Renal Data System. USRDS 2007 Annual Data Report. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services; 2007. 3. National kidney and urologic diseases information clearinghouse: Kidney disease of diabetes

4. 1.National kidney foundation : diabetes and kidney disease; 2.National kidney and urologic diseases information clearinghouse: Kidney statistics for the United State 3.Érika B Rangel, João R de Sá, Cláudio S Melaragno, Adriano M Gonzalez, Marcelo M Linhares, Alcides Salzedas and José O Medina-Pestana. Kidney transplant in diabetic patients: modalities, indications and results. Diabetology & Metabolic Syndrome 2009, 1:2 doi:10.1186/1758-5996-1-2

5. 1. National kidney and urologic diseases information clearinghouse: Kidney disease of diabetes

8. Participant characteristics TABLE 1.PREVALENCE OF KIDNEY TRANSPLANTATION AND MORTALITY BY KIDNEY TRANSPLANTATION N=658%(N)Mortality(%,n)p-value No kidney transplant 90.58(596)22.65(135) Kidney transplant 1 kidney transplant 2 kidney transplant 9.42(62) 83.87(52/62) 16.13(10/62) 46.77(29) 48.08(25) 40.00(4) <0.0001 TABLE 2.CAUSE OF DEATH IN THOSE WITH KIDNEY TRANSPLANTATION N=28%(N) Diabetic renal disease 21.43(6) Acute complications 10.71(3) Coronary artery disease 46.43(13) Infections 17.86(5) Other- diabetes 3.57(1)

9. CharacteristicTotal (n=658) No kidney transplant(n=596) kidney transplant(n=62) p-value Age (years)27.03(21.92,33.31)26.5(21.47,32.94)31.9(26.5,35.4)0.0001 Sex, N(%) Men Women 333(51) 325(49) 298(50) 35(56.45) 27(43.55) 0.3335 Duration of diabetes(years) 18.5(13.23,25.5)18.17(12.73,24.79)24.37(18.5,28.44)0.0001 BMI(kg/m2) 23.33(21.36,25.44)23.36(21.34,25.49)22.79(21.55,24.86)0.3138 SBP(mmHg)111(104,121)110(103,119)124.5(116,137)<.0001 DBP(mmHg)72(66,79)71(65,79) 80.5(74,91)<.0001 WBC(cells/mm3)6.2(5.3,7.6)6.2(5.3,7.4)6.9(5.7,8.6)0.0020 Total cholesterol(mg/dl) 184(162,215)182(161,212)208.5(173,247)0.0001 HDL(mg/dl)52.2(45.1,60.8)52.55(45.5,60.95)48.1(41.4,56.9)0.0108 LDL(mg/dl)110.8(91.8,133.6)109.8(90.6,131.4)131(107.8,161.6)0.0001 Triglycerides(mg/ dl) 83(61,126)80(59,118)127(81,182)0.0001 Albumin excretion rate( μ g/min) 16.49(7.55,168.56)13.68(7.2,89.67)711.19(100.8,1808.6)<.0001 Table 3. Population characteristics by kidney transplantation [median(q1,q3)]

10. Table 4: Characteristics of participants who underwent kidney transplantation by subsequent survival status Data are median (q1,q3) for normally distributed and mean(SD) for non normal continuous variables

11. Table 5:Age adjusted hazard ratios for mortality risk among participants with one or more Kidney transplant *log transformed ^not adjusted for age

12. *Model adjusted for age, DBP