1. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Bileaflet mechanical heart valve model Figure Legend:

2. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Enlargement of jet region Figure Legend:

3. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Horizontal mock circulatory loop Figure Legend:

4. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Details of the acrylic valve model Figure Legend:

5. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Typical loading rates during valve closure. Symbols represent the closure time of each leaflet. (Open=leaflet proximal to pressure transducer; solid=distal leaflet). Figure Legend:

6. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Typical pressure wave forms (P2) measured ∼ 2mm downstream of the leaflet surface. Symbols represent the closure time of each leaflet. Open=leaflet proximal to pressure transducer; solid=distal leaflet. Figure Legend:

7. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Comparison of the predicted minimum pressure to experiment at a low flow condition Figure Legend:

8. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Comparison of the predicted minimum pressure to experiment at a high flow condition Figure Legend:

9. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Comparison of the predicted closing time to experiment Figure Legend:

10. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Comparison of the predicted minimum pressure (P2) to experiment Figure Legend:

11. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Comparison of the predicted angular position to experiment Figure Legend:

12. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Predicted angular rates at closure match experimental trends Figure Legend:

13. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Predicted minimum pressure is significantly affected by a change in initial or final conditions for a constant dP∕dt=200mmHg∕s Figure Legend:

14. Date of download: 6/23/2016 Copyright © ASME. All rights reserved. From: Lumped Parameter Model for Computing the Minimum Pressure During Mechanical Heart Valve Closure J Biomech Eng. 2005;127(4):648-655. doi:10.1115/1.1934164 Simulation suggests that cavitation inception trends developed using the loading rate are likely to produce inconsistent results due to the variability in initial or final conditions and waveform shape. Solid=simulation; open=experimental. Figure Legend: