1. Large black circles: query genes grey circles: interacting or related proteins Light grey line: consolidated pathways Yellow: predicted pathways Green: Genetic interactions Red: Physical interaction Suppl 3A

2. Large black circles: query genes grey circles: interacting or related proteins Purple: Co-expression Functions 1. Regulation of Ras GTPase activity 2. Regulation of Rho GTPase activity 3. Regulation of purine nucleotide catabolic process Suppl 3B

3. Large black circles: query genes grey circles: interacting or related proteins Red: Physical interaction Orange: Predicted Light blue: Pathway Dark blue: Colocalization Ochre: Shared protein domain Green: Genetic interaction Functions 1. Cellular response to type I interferon 2. Response to virus 3. Regulation of nuclear division, mitosis, viral genomic replication 4. Ubiquitin ligase complex, anaphase promoting complex Suppl 3C

4. Large black circles: query genes grey circles: interacting or related proteins Purple: Co expression Functions 1. Component of ECM 2. Cell substrate adhesion Suppl 3D

5. Large black circles: query genes grey circles: interacting or related proteins Grey: Consolidated pathways Red: Physical interactions Orange: predicted Light blue: Pathway Grey diamond: MirRNA targets predicted Functions 1. Axon guidance 2. Collagen fibril organization and ECM component 3. PDGF binding 4. ER lumen 5. Skin development 6. Ras, Rho protein signal transduction 7. Epidermis, skeletal system development 8. Regulation of cell migration Suppl 3E

6. Large black circles: query genes Grey circles: interacting or related proteins Grey: Consolidated pathways Red: Physical interactions Orange: predicted Light blue: Pathway Grey diamond: MirRNA targets predicted Functions 1. Axon guidance 2. Collagen fibril organization and ECM component 3. PDGF binding 4. ER lumen 5. Skin development 6. Ras, Rho protein signal transduction 7. Epidermis, skeletal system development 8. Regulation of cell migration 9. Cell junction assembly, cell matrix adhesion 10. Unfolded protein binding Suppl 3F

7. Large black circles: query genes Grey circles: interacting or related proteins Red: Physical interactions Orange: predicted interaction Light blue: Pathway Light green: genetic interactions Functions 1. Regulation of Mitosis, organelle fission 2. Anaphase promotinc complex dependent ubiquiting dependent protein catabolism 3. Spindle fiber organization 4. Negative regulation of ubiquitin protein ligase activity involved in mitosis Suppl 3G