1. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Flowchart of subject disposition. ITT indicates intent-to-treat; PP, per-protocol. Figure Legend:

2. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Maintenance rates (percentage of subjects maintaining at least 50% improvement in lesion counts; intent-to-treat population, worst case). Figure Legend:

3. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Total (A), inflammatory (B), and noninflammatory (C) lesion counts (intent-to-treat population). Figure Legend:

4. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Effect of 16 weeks of maintenance therapy with adapalene gel, 0.1%, following 12 weeks of combination therapy with adapalene gel, 0.1%, plus doxycycline on severe facial acne lesions. Photographs show subject treated with doxycycline and adapalene gel, 0.1%, at baseline of the combination study (A); after 12 weeks of combination treatment with adapalene gel, 0.1%, plus doxycycline (this time point is also the baseline for the maintenance study) (B); and following 16 weeks of maintenance treatment with adapalene gel, 0.1% (C). Figure Legend:

5. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Local tolerability. Effects of adapalene gel, 0.1%, vs gel vehicle on mean scores for skin tolerance variables of erythema (A), scaling (B), dryness (C), and stinging and/or burning (D). Skin tolerability variables were assessed according to the following scoring scale: none = 0, mild = 1, moderate = 2, and severe = 3. Mean scores at each postbaseline visit and worst score (worst observation recorded for a subject during the postbaseline period) are included in the figure. Figure Legend:

6. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Adapalene Gel, 0.1%, as Maintenance Therapy for Acne Vulgaris: A Randomized, Controlled, Investigator-Blind Follow-up of a Recent Combination Study Arch Dermatol. 2006;142(5):597-602. doi:10.1001/archderm.142.5.597 Five-question subject survey. A, Adverse effects? B, Treatment effectiveness? C, How do you feel about yourself? D, Overall maintenance treatment? E, Overall treatment scheme? Figure Legend: