1. Neurons: Functional Units of the Nervous System http://www.denniskunkel.com/product_info.php?products_id=1406

2. Structure of a Neuron http://www.healthline.com/galeimage?contentId=gemd_02_00265&id=gemd_02_img0071 Axon Dendrites Soma Synapse Myelin

3. Neuron Morphologies http://health.howstuffworks.com/human-body/systems/nervous-system/brain-pictures24.htm

4. Purkinje Cells – by Cajal http://en.wikipedia.org/wiki/File:PurkinjeCell.jpg

5. Hippocampus Pyramidal Cells http://faculty.washington.edu/chudler/ca1pyr.html

6. Giant Motor Neuron http://www.cnqhkj.com/imageRepository/6929e31c-c1cb-4706-8da1-94eb703cb76f.jpg

7. The Resting Potential + Na + K+K+ - OUT IN Na + K+K+ K+K+ V m = -70 mV The Na + /K + Pump

8. Measuring Membrane Voltage Borrowed from: http://www.cns.nyu.edu/~david/courses/perception/lecturenotes/brain/brain-slides/Slide14.jpg

9. Ion Channels: Voltage Gated vs. Ligand Gated http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=.0oZ6eBya5nos4Z6WzX4Qx1bofq42XcqFV-Do_f

10. K + Channel: Molecular Structure http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=.0NyAufMyMBoGPNNu2- YWEOYyMMDZFvburfsTAG

11. Comparing Molecular Structures of Na +, Ca ++, K + and Cl - Ion Channels http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=.03JJKlpNx3F1lfjk892Y0U6EkYLtnMBw9sVjGl

12. Action Potentials http://en.wikipedia.org/wiki/Action_potential V m = -70 mV + - OUT IN Na + K+K+ K+K+ K+K+ - OUT IN K+K+ Na + K+K+ K+K+ + + - OUT IN Na + K+K+ K+K+ K+K+ K+K+ V m = +40 mV V m = -80 mV 0-1, 5 Time (ms) 1-2 2-3

13. Conduction of Electrical Impulse

14. Wave of Depolarization http://en.wikipedia.org/wiki/Action_potential

15. Saltatory Conduction in Mylenated Axons

16. The Synapse http://txtwriter.com/Backgrounders/Drugaddiction/drugs1.html axo-dendritic synapse axo-somatic synapse axo-axonic synapse

17. Synapses on a Cell Body http://txtwriter.com/Backgrounders/Drugaddiction/drugs1.html

18. Synapses On a Hippocampal Neuron http://molneuro.kaist.ac.kr/psd Visualization of synaptic sites by synaptophysin immunostaining on cultured hippocampal neurons

19. Structure of the Synapse PSD http://txtwriter.com/Backgrounders/Drugaddiction/drugs1.html

20. Synaptic Transmission http://science.education.nih.gov/supplements/nih2/addiction/guide/lesson2-2.htm Steps: 1.Nerve impulse 2.Ca ++ influx 3.Vesicle fusion/neurotransmitter release 4.Postsynaptic signal transduction 5.Degradation/reuptake

21. Summation of Post-Synaptic Potentials: Threshold http://en.wikipedia.org/wiki/Excitatory_postsynaptic_potential

22. Excitatory vs. Inhibitory Post-Synaptic Membrane Potentials http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=.0Er9KhNfOCKpqqb4-qnqpkJJSFWpTO3SH3S7hb EPSP IPSP

23. Excitatory vs. Inhibitory Synapses Excitatory: asymmetrical Inhibitory: symmetrical D: dendrite http://faculty.washington.edu/chudler/java/em.html

24. Synapse Quiz www.DennisKunkel.com C A D B E F Word Bank 1.presynaptic cell 2.postsynaptic cell 3.transmitter vesicles 4.synaptic gap or cleft 5.PostSynaptic Density (PSD) 6.mitochondrion

25. Neurotransmitters in the Brain acetylcholine http://commons.wikimedia.org/wiki/File:Acetylcholine.png Amino Acids: Mono-amines: Peptides: Others: glutamateGABA serine serotonin dopamine histamine B-endorphin http://en.wikipedia.org/wiki/Glutamate http://en.wikipedia.org/wiki/D-serine http://en.wikipedia.org/wiki/%CE%93-aminobutyric_acid http://en.wikipedia.org/wiki/Serotonin http://en.wikipedia.org/wiki/Dopamine http://en.wikipedia.org/wiki/Histamine http://en.wikipedia.org/wiki/File:Beta-endorphin.png excitatory inhibitory both

26. Effects of Cocaine on Dopamine Reuptake http://www.humanillnesses.com/images/hdc_0000_0001_0_img0085.jpg Cocaine blocks dopamine reuptake, enhancing the effect of dopamine in the brain’s “pleasure” center