1. Project Coordinator Laura Leone GARR The Italian Academic and Research Network Italy Laura.leone@garr.it From neurological research to clinical praxis: a European e-Service to support the early diagnosis of neurodegeneration EC Call: FP7-INFRAS-2010-2 – VRC Contract n°: RI-261593 Project type: CP-CSA Duration: 24 months Total budget:2’580’558 € EC Funding: 2’399’998€ Project participants: 1 CONSORTIUM GARR IT 2 CNR IT 3 CONSORZIO COMETA IT 4 FATEBENEFRATELLI IT 5 UNIVERSITY SAN RAFFAELE IT 6 UNIVERSITY OF GENOA IT 7 UNIVERSITY OF FOGGIA IT 8 FONDAZIONE SDN IT 9 MAAT FRANCE FR 10 IMPERIAL COLLEGE UK 11 UNIWERSYTET WARSZAWSKI PL 12 CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE - FR 13 ALZHEIMER EUROPE LU CHAIN Project KoM 13 th December

2. CHAIN KoM Rome 13 th December 2010 2 The DECIDE project goals To provide the Neuroscientific and Medical community with a dedicated Grid-based e- Infrastructure relying on Neugrid and GEANT To deploy a secure and user-friendly service for the early diagnosis and research on dementia and other brain diseases linking large distributed DBs of multimodal neuroimages To validate the e-Infrastructure and the services through application to real patient cases To propose a long-term vision for the sustainability of the e- Infrastructure and its extension to new communities and pathologies To disseminate the results and provide training programmes promoting the adoption of the DECIDE e-Infrastructure and service.

3. CHAIN KoM Rome 13 th December 2010 3 DECIDE reference infrastructures Designed with NeuGRID starting core as a reference infrastructure MRI-based algorithms developed within NeuGRID will be endorsed by DECIDE OutGRID will act as the external gateway to liaise to other international infrastructures ( e.g. LONI, CBRAIN ) Both OutGRID & NeuGRID will also provide their outcomes w.r.t. data access policies, user requirements and standards to the DECIDE project Transferring results among projects will be eased by their expected timing GridSPM alghorithm, PET/SPECT based, is already deployed as diagnostic pilot at national scale

4. CHAIN KoM Rome 13 th December 2010 4 Strategic ideas behind the project Widening the access to highly specialized tools and techniques CIVET/ADABoost – RMI images GridSPM – Pet/SPECT images EEG patterns Building a European reference e-Services pilot project including its own e-Infrastructure progressive extension of e-Science in the domain of neurology Providing the new European Virtual Research Communities with powerful diagnostic tools currently available only to a restricted number of clinicians.

5. CHAIN KoM Rome 13 th December 2010 5 DECIDE Workplan - I3 Project structure Networking Activities Overall coordination of the project (NA1) Creation stable liaisons with relevant stakeholders in the scientific and eInfrastructure domains (NA2) dissemination of results and reaching out to the medical community, (NA3) Service Activities Network and GRID provisioning and management (SA1) Exposing the medical database to the applications running on the e-Infrastructure (SA2) Research and development Activities Porting of the diagnostic alghorithms (JRA1) Design of the diagnostic service (JRA2) User validation and Testing (JRA3)

6. CHAIN KoM Rome 13 th December 2010 6 DECIDE layering structure

7. CHAIN KoM Rome 13 th December 2010 7 E-Service final infrastructure

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10. CHAIN KoM Rome 13 th December 2010 10 Our requirements: what we need Access to very large European, even global, biomedical images distributed repositories Many processing resources to faster the extraction of bio-markers Collaboration with Projects which will assure standard services Feedback from clinical communities

11. CHAIN KoM Rome 13 th December 2010 11 GEANT & NRENs = EUROPEAN GATEWAY FOR RESEARCH Network access GÉANT collaboration & support EGI AND EMI STANDARDS AND COMMUNITY REQUIREMENTS Harmonization with EGI-EMI standards US-ADNI, NEST-DD MEDICAL PHARMACOG DATA COLLECTION Infrastructure and middleware standards Medical Data Collection DECIDE Ethical & legal, business model & extension DECIDE AUPs approval/authorization procedure Data collections neuGRID, LONI, CBRAIN, outGRID, EADC, PHARMACOG Algorithms, database, Grid repository, users Experts in Medical Physics, Mathematicians, Neurologists, Scientific international Collaboration DATA&EXPERTISEDATA&EXPERTISE DATA&EXPERTISEDATA&EXPERTISE Expected DECIDE exploitation

12. CHAIN KoM Rome 13 th December 2010 12 Thank you for your kind attention! For further information please contact laura.leone@garr.it info@eu-decide.eu http://www.eu-decide.eu laura.leone@garr.it http://www.eu-decide.eu