2. و قل رب زدني علما صدق الله العظيم. سورة طه آية 114

3. Respiratory Disorders Associated With Acute Respiratory Failure http:// telemed.shams.edu.eg/moodle5

4. Definition: The term Acute Respiratory Failure (ARF ) is used clinically to indicate a disease or disorder of the respiratory system, recent in onset, which has resulted in a level or pattern of external gas exchange that is inadequate for the metabolic needs of the body.

5. This deficiency is reflected in arterial hypoxemia, hypercapnia and respiratory acidosis. If the initiating mechanism is not arrested, corrected & reversed the abnormalities in the blood gases are apt to progress to intolerable levels. There is no precise level of arterial Po 2 or Pco 2 that defines [ARF]. However, an arterial P a o 2 < 50-60 mmHg can be life threatening because further impairment of gas exchange can cause a drop in P a o 2 to levels that would compromise Oxygen Delivery [Do 2 ] to vital organs.

6. Acute rise of PaCo 2 to >50 mmHg i.e. Acute Hypercapnia with Respiratory Acidosis result in mental confusion, depressed sensorium that end in coma and death. The effects of acute hypoxemia and acute hypercapnia may overlap, resulting in severe C. N. S depression.

7. The respiratory apparatus consists of two components : 1- Pump system: includes the entire ventilatory apparatus [Respiratory Center, Thoracic Cage, Air ways]. 2- Gas Exchange system : pulmonary parenchyma [alveoli with alveolar air & alveolo-capillary membrane.

8. Respiratory Failure can therefore be divided into :  Pump Failure or hypercapnic respiratory failure with Co 2 retention.  Lung Failure or gas exchange failure with arterial hypoxemia i.e. hypoxemic respiratory failure.

9. I- Lung Failure (Hypoxemic Respiratory Failure):  Adult respiratory distress syndrome ARDS.  Cardiogenic pulmonary edema.  End stage pulmonary fibrosis, resulting from different fibrotic lung diseases.  Massive Pulmonary Embolism.  Severe Pneumonia.

10. II. Pump Failure ( hypercapnic respiratory failure )  Neuromuscular disease, atrophic or pseudo hypertrophic myopathies.  Guillain Barre syndrome.  Myasthenia gravis.  Amyotrophic lateral sclerosis.  Cervical quadriplegia.  Botulism.

11.  Respiratory Poliomyelitis.  Bilateral diaphragmatic paralysis.  Hereditary myopathies.  Multiple sclerosis.  Collagen vascular disease e.g. vanishing lung syndrome in SLE..  Central nervous disorders “C.V.S”.  Drug over dose.  Head trauma.

12.  Hypothyroidism e.g. myxedema coma.  Brain stem infarction& brain neoplasm.  Disorders of the chest bellows.  Kyphoscoliosis & Chest wall deformities.  Chest trauma and Flail Chest.  Tension pneumothorax.  Massive pleural effusion.  Airway obstruction.

13.  Acute severe asthma.  Chronic Obstructive Pulmonary Disease COPD.  Anaphylaxis  Cystic fibrosis  Upper airway obstruction e.g. Epiglottitis& Foreign body inhalation.

14. Pump failure: hypercapnic respiratory Failure Hypercapnia due to respiratory failure can arise In one of two ways: 1) Alveolar hypoventilation secondary to a subnormal low minute ventilation. 2)Ventilation-Perfusion (V /Q ) mismatch.

15. Pathophysiologic mechanisms in Acute Respiratory Failure: MechanismType of failureFeature Global alveolar hypoventilation PumpHypercapnia Ventilation – perfusion mismatch Pump and /or lungHpercapnia and /or hypoxemia ShuntLungHpoxemia Diffusion abnormality LungHpoxemia

16. Patients who need oxygen  Cardio pulmonary Resuscitation [CPR] in Respiratory or Cardio pulmonary arrest.  Fluid in the alveoli. Pulmonary edema. Pneumonia. Near drowning.

17. Chest trauma.  Collapsed alveoli (alveolar atelectasis ) as in cases of : a) Airway obstruction : Any unconscious patient. Choking & FB inhalation. b) Failure to take deep breaths : Severe pain as in rib fracture & severe pleurisy ).  Paralysis of the respiratory muscles.

18.  Depression of the respiratory center (head injury,drug overdose ) c) Collapse of an entire lung (pneumothorax or massive pleural effusion )  Other gases in the alveoli : a) Smoke inhalation. b) Toxic inhalations. c) Carbon monoxide poisoning.

19.  Any patient complaining of shortness of breath.  Any patient in shock.  any patient with signs of respiratory insufficiency.  Any patient breathing fewer than 10 times / minute i.e. bradypnea.  Any patient in cardiac arrest.

20.  Any patient complaining of chest pain.  Any patient suspected to be suffering a stroke. ( Caroline, 1995 )