1. Kyung Hee University, Seoul, Korea Conference LGI Conference Presented by Byeong-Joo Noh Supervised by Youn-Wha Kim Kyung Hee University, Seoul, Korea

2. CASE 1 M/61 2015.04.24 Colon and Rectum, Biopsy (x8) 2015.05.07 Sigmoid colon, LAR

3. Kyung Hee University, Seoul, Korea Colon, Sigmoid, Biopsy S-2015-06274 x40 Adenocarcinoma, moderately differentiated

4. Kyung Hee University, Seoul, Korea Colon, Descending, Biopsy S-2015-06274 x40 Hyperplastic polyp

5. Kyung Hee University, Seoul, Korea Colon, Sigmoid, Biopsy S-2015-06274 x40 Hyperplastic polyp

6. Kyung Hee University, Seoul, Korea Rectum, Biopsy S-2015-06274 x40 Hyperplastic polyp

7. Kyung Hee University, Seoul, Korea Sigmoid colon, LAR S-2015-06918

8. Kyung Hee University, Seoul, Korea Sigmoid colon, LAR S-2015-06918

9. Kyung Hee University, Seoul, Korea CASE 2 F/18 2013.01.16 Terminal ileum to Rectum, Bx (x4) 2013.07.23 Perianal skin, Biopsy 2013.11.05 Anus, Biopsy

10. Kyung Hee University, Seoul, Korea Terminal ileum, Biopsy S-2013-00869 x40

11. Kyung Hee University, Seoul, Korea Terminal ileum, Biopsy S-2013-00869 x200

12. Kyung Hee University, Seoul, Korea Terminal ileum, Biopsy S-2013-00869 x200

13. Kyung Hee University, Seoul, Korea Terminal ileum, Biopsy S-2013-00869 x200 Chronic granulomatous inflammation

14. Kyung Hee University, Seoul, Korea Ascending colon, Biopsy S-2013-00869 x40 Chronic inflammation with lymphoid hyperplasia

15. Kyung Hee University, Seoul, Korea Transverse colon, Biopsy S-2013-00869 x40

16. Kyung Hee University, Seoul, Korea Transverse colon, Biopsy S-2013-00869 x200 Chronic granulomatous inflammation

17. Kyung Hee University, Seoul, Korea Rectum, Biopsy S-2013-00869 x40 Chronic inflammation

18. Kyung Hee University, Seoul, Korea Perianal skin, Biopsy S-2013-12329 Acute and chronic inflammation (Abscess)

19. Kyung Hee University, Seoul, Korea Anus, Biopsy S-2013-18605 Fistular tract with acute and chronic inflammation

20. Kyung Hee University, Seoul, Korea CASE 3 M/67 2015.01.16 Rectum, Biopsy 2015.04.28 Rectum, Biopsy Rectum, TME

21. Kyung Hee University, Seoul, Korea Rectum, Biopsy S-2015-00194 x40 Adenocarcinoma, moderately differentiated

22. Kyung Hee University, Seoul, Korea Rectum, Biopsy S-2015-06488 x40 No tumor (Chronic inflammation) (History of rectal cancer s/p concurrent chemoradiation therapy)

23. Kyung Hee University, Seoul, Korea Rectum, Total mesorectal excision S-2015-06505

24. Kyung Hee University, Seoul, Korea Rectum, Total mesorectal excision S-2015-06505

25. Kyung Hee University, Seoul, Korea Rectum, Total mesorectal excision S-2015-06505

26. Kyung Hee University, Seoul, Korea Tumor Regression Grade by Dworak (Int J Colorect Dis 1997;12:19-23) Grade 0: no regression; Grade 1: dominant tumor mass with obvious fibrosis and/or vasculopathy; Grade 2: dominantly fibrotic changes with few tumor cells or groups (easy to find); Grade 3: very few (difficult to find microscopically) tumor cells in fibrotic tissue with or without mucous substance; Grade 4: no tumor cells, only fibrotic mass (total regression or response)

27. Kyung Hee University, Seoul, Korea Rectum, Total mesorectal excision S-2015-06505 x40

28. Kyung Hee University, Seoul, Korea Rectum, Total mesorectal excision S-2015-06505 x40

29. Kyung Hee University, Seoul, Korea Diagnosis Rectum, total mesorectal excision: Adenocarcinoma, moderately differentiated, rectum (post neoadjuvant treatment status) 1) Tumor size: 2.5 cm x 1.0 cm x 1.0 cm 2) Tumor gross type: Ulceroinfiltrative 3) Depth of invasion: Tumor invades subserosa (ypT3) 4) Margins of resection: No tumor (safety margin: proximal 9.5 cm, distal 3.0 cm) 5) Lymphatic invasion: Not identified 6) Vascular invasion: Not identified 7) Perineural invasion: Not identified 8) Regional lymph nodes: No metastasis in 13 regional lymph nodes (0/13, pN0) 9) Tumor budding: Insignificant (1-5/ x200) 10) Tumor regression grade: Minimal regression (1)

30. Kyung Hee University, Seoul, Korea CASE 4 F/51 2012.06.26 Rectum, Px 2012.11.15 Rectum, Bx 2014.11.17 Colorectum, Bx and Px (x3) 2015.04.28 Colorectum, Bx (x3) 2015.05.08 Rectum, Bx (x2)

31. Kyung Hee University, Seoul, Korea Rectum, 1 cm from anal verge, Polypectomy S-2012-10293 X12.5

32. Kyung Hee University, Seoul, Korea Rectum, 1 cm from anal verge, Polypectomy S-2012-10293 X40

33. Kyung Hee University, Seoul, Korea Rectum, 1 cm from anal verge, Polypectomy S-2012-10293 X200

34. Kyung Hee University, Seoul, Korea Diagnosis Rectum, 1cm from anal verge, polypectomy: Adenocarcinoma in situ, well differentiated 1) Size: 1x0.8 cm 2) No invasion of lamina propria 3) Clear deep resection margin (safety margin: 0.2 cm) 4) Lymphovascular invasion: not identified

35. Kyung Hee University, Seoul, Korea Rectum, Biopsy S-2012-19236 X40 Chronic inflammation

36. Kyung Hee University, Seoul, Korea Transverse colon, Polypectomy S-2014-00987 X40 Tubular adenoma with low grade dysplasia

37. Kyung Hee University, Seoul, Korea Transverse colon, Biopsy S-2014-00987 X40 Tubular adenoma with low grade dysplasia

38. Kyung Hee University, Seoul, Korea Rectum, just above the anal verge, Biopsy S-2014-00987 X40 Chronic inflammation

39. Kyung Hee University, Seoul, Korea Colon, 15cm from anal verge, Biopsy S-2015-06539 X40 Tubular adenoma with low grade dysplasia

40. Kyung Hee University, Seoul, Korea Colon, 12cm from anal verge, Biopsy S-2015-06539 X40 Tubular adenoma with low grade dysplasia

41. Kyung Hee University, Seoul, Korea Rectum, anal verge, Biopsy S-2015-06539 X40 Chronic inflammation

42. Kyung Hee University, Seoul, Korea Rectum, 12cm from anal verge, Biopsy S-2015-07001 X40 Tubular adenoma with low grade dysplasia

43. Kyung Hee University, Seoul, Korea Rectum, 12cm from anal verge, colonoscopic biopsy S-2015-07001 X40 Tubular adenoma with low grade dysplasia

44. Kyung Hee University, Seoul, Korea CASE 5 F/69 2015.05.07 Rectum, Biopsy

45. Kyung Hee University, Seoul, Korea Rectum, 20cm anal verge, Biopsy S-2015-06932 X40 Chronic ulcer