1. Reverse Medical Integration Project Plan
Dr. Petra Brockfeld
November 2014

2. UNO™ - Neurovascular Embolization Device
The UNO™ Neurovascular Embolization System is indicated to obstruct blood flow in the Neuro vasculature.
“Revolutionary”
Fast, Predictable, super-selective
Microcatheter deliverable
Resheathable (100% and multiple)
Electrolytically detachable
FDA filed, CE Mark approved
Unconstrained Constrained
Diameter (A) Length (B) Diameter (A) Length (B) Delivery
UNO mm 12 mm mm mm 021
UNO mm 12 mm mm mm 027
Covidien | September 02, 2014 | Confidential

3. UNO™ in Clinical Practice
48 yo Male (headaches, blurred vision)
Giant right PCA Aneurysm (25h X 30w X 20n mm)
Aneurysm 50-60% thrombosed
PCA beyond repairable
Balloon test occlusion successful
Immediate TIMI-0, 31 second detachment
Patient awoke symptom free
Dr. Sakai: “021 and UNO were wonderful”
Nobuyuki Sakai, MD, Kobe Japan
PCA- Large fusiform Aneurysm
Covidien | September 02, 2014 | Confidential

4. Barrell™ Vascular Reconstruction Device (VRD)
The Barrel™ Vascular Reconstruction Device (VRD) is intended for use with embolic coils for the treatment of wide-neck (≥4 mm), intracranial aneurysms located at a bifurcation or arising at a branch site in a parent vessel with a diameter of ≥ 2 mm and ≤ 4mm. C E D B A
Order
Number
Recommended Vessel Sizes
A. Proximal End Diameter
B. Distal End Diameter
C. Barrel Diameter
D. Barrel Length
E. Usable Length
BV-3550 mm
3.5mm
3.0mm
5.0mm
20mm
BV-3560
6.0mm
BV-4065 mm
4.0mm
6.5mm
BV-4070
7.5mm
7.0mm
21mm
BV-4580 mm
4.5mm
8.0mm
22mm
Covidien | September 02, 2014 | Confidential

5. Barrell™ VDR Performance in Bifurcation Aneurysm
Covidien | September 02, 2014 | Confidential