1. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative “CJDI – A Success Story Update on progress and next steps” Presentation to Industry Forum December 8, 2010 Ottawa, Ontario

2. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative WHY- MAP 101? MAP (Mycobacterium avium paratuberculosis) causes JD in ruminants. MAP hides from the immune system, multiplies in the gut, and damages cells that absorb nutrients. Infected animals develop chronic diarrhea, lose weight, get thin, and eventually die. Young animals are exposed to infection via manure, udder, milk, bedding, uterus, water and feed (adults susceptible if exposed to high levels of MAP). MAP does not multiply in the environment, but can survive in manure, water and pastures for many months.

3. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative WHY? JD can be a very significant production-limiting disease: o recent US dairy study: MAP+ cows yielded 1,355 kg less milk/lactation = $1,000 CAD Crohn’s Disease association (non-conclusive research) risk : o Food safety- MAP bacteria in meat tissue/products of MAP+ animals o Foreign and domestic market impact o Potential non-tariff trade barrier

4. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Delivered by Canadian Animal Health Coalition for: o Dairy Farmers of Canada (DFC) o Canadian Cattlemen’s Association (CCA) Launched in July, 2009 Farm management assistance approach (not regulatory) Collaboration by provinces, industry, governments and universities Provinces deliver own programs

5. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johnes Disease Initiative Priorities 1.Education and awareness 2.Provincial program encouragement and coordination 3.Research support and facilitation

6. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Priorities’ Update 1. Education and awareness Quarterly CJDI newsletters (>140 Canadian contacts) and web page (CAHC site) Beef- CCA Action News, Canadian Cattlemen, Canadian Meat Business, Cattle Country, BCRC Research, CJDI beef brochures to individual producers, CCA web site Dairy- DFC Key Messages (JD/Crohn’s), Milk Producer, Western Dairy Farmer, Ontario Farmer, Ceptor, CJDI dairy brochures to individual Canadian milk producers, DFC web site

7. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Priorities’ Update 2.Provincial program and activities’ progress: Atlantic (Agri-flexibility/industry application… $2.3M- 4 yr) Programme volontaire de prévention et de contrôle de la paratuberculose au Québec ($1M- past 3 yr; $600K- next 3 yr) Ontario JD Education & Management Assistance Program ($2.4M- 4 yr) Manitoba (Fed/Prov GF- FS, MAFRI and DFM… $175K- 2 yr) Saskatchewan JD Working Group Alberta JD Initiative (ALMA, AB Milk, U of Calgary… $0.7M- 3yr) BC JD Working Group (GF- FS beef project… $60K- 1 yr)

8. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Priorities’ Update 3. Research: support MAP Researchers’ Meetings (3 rd Annual in Banff- October, 2010) support individual JD/MAP research applications (eg Atlantic Innovation Fund, NSERC and Adaption Canada “collective outcomes”) Technical Committee meetings (recommendations re provincial program standards- eg dairy farm risk assessment and management practices)

9. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Research Collaboration Example i) UCVM, AB: JD Infection of Calves and early MAP markers (DeBuck et al) o MAP dose and calf age affects o Gene profiling, metabolomic, mass spectrometry, immunological techniques o $1M in funding by AB Funding Consortium/AB Ingenuity, DFC-PESAC & NSERC ii) WCVM, SK: Low Dose MAP Vaccination of Calves (Hendrick et al) o Intradermal skin testing, early immune response, etc o $275,000 from BCRC, SK Ag Development Fund and Westgen AI Centre iii) U of Manitoba: Microbial-based MAP Diagnostics (Krause et al) o Calf gut tissue from the 2 above research trials o Understanding MAP microbiology and identifying co-infection possibilities o $255,000 from CAAP >$1.5 M of excellent, complementary collaborative research re MAP

10. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Other Ruminants September 2010, C Bauman commenced a 3-year PhD program at the University of Guelph in small ruminant JD epidemiology, disease modelling, and diagnostic test evaluation. CJDI Newsletter updates of current JD information and intelligence provided to national sheep, goat, cervid and bison industry contacts. JD management brochures available to sheep and goat producers- http://www.johnesdisease.org/Educational%20Material.html

11. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Technical Committee Herman Barkema, University of Calgary (co-chair) Shawn McKenna, University of Prince Edward Island (co-chair) Gilles Fecteau, University of Montreal David Kelton, University of Guelph Steve Hendrick, University of Saskatchewan Reynold Bergen, Canadian Cattlemen’s Association Elizabeth Cork, Dairy Farmers of Canada Amanda Amaratunga, Canadian Food Inspection Agency Ann Godkin, Ontario Johne’s Education and Management Assistance Program Geneviève Côté, Programme volontaire de prévention et de contrôle de la paratuberculose au Québec

12. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Advisory Committee Pauline Duivenvoorden, Dairy Farmers of Canada (co-chair) Pat Rutledge, Canadian Cattlemen’s Association (co-chair) Louis Desautels, Canadian Cattlemen’s Association Elizabeth Cork, Dairy Farmers of Canada Ron Versteeg, Ontario Johne’s Education and Management Assistance Program Geneviève Côté, Programme volontaire de prévention et de contrôle de la paratuberculose au Québec Herman Barkema, University of Calgary Shawn McKenna, University of Prince Edward Island

13. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative Going Forward Extended CJDI commitment through 2011 by Continued facilitative support to JD awareness and education, provincial program development and research collaboration Expanded CJDI focus in 2011: o Other ruminant species o Fit with on-farm disease bio-security Small ruminant representation on JD working groups Increased JD activity and program-building momentum, resulting from strong support by industry, academia and government

14. Canadian Animal Health Coalition Promoting a collaborative approach to animal health Canadian Johne’s Disease Initiative THANK YOU for your support Canadian Johne’s Disease Initiative (CJDI) http://www.animalhealth.ca/CJDI Initiative Canadienne de Prevention de la Paratuberculose (ICPP) http://www.animalhealth.ca/ICPP Ron Barker, CJDI Coordinator Ed Empringham, CJDI Manager