1. Date of download: 5/31/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease Arch Gen Psychiatry. 1998;55(3):215-224. doi:10.1001/archpsyc.55.3.215 Histogram comparison of the neuronal soma size distribution between control (CTRL), schizophrenic (SCHIZ), and Huntington diseased (HD) brains in layers III, IV, V, and VI of prefrontal area 9. Solid lines represent curves of normal distribution in diseased brains whereas dotted lines depict control brains. Solid bars represent the number of soma in specific size ranges in diseased brains. Hatched bars represent soma size in control brains. Notice that in cortical layers III and V of both schizophrenic and HD brains, the curves of normal distribution are shifted toward smaller sizes when compared with controls. In layer VI, a pronounced shifting of the normal distribution curve is observed only in HD but not schizophrenic brains. In contrast, no departures from the control group's normal distribution were observed in either schizophrenic or HD brains in layer IV. Figure Legend:

2. Date of download: 5/31/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease Arch Gen Psychiatry. 1998;55(3):215-224. doi:10.1001/archpsyc.55.3.215 Plots summarizing results of regression analyses in prefrontal area 9. Correlation between neuronal soma size in sublayer IIIc and cortical thickness, neuronal density, glial density, age, postmortem interval (PMI), and time in formalin (TF) is shown on individual plots. Note that in layer IIIc there were significant positive correlations between soma size and cortical thickness and negative correlations between mean soma size and neuronal and glial density. No significant interactions between age, PMI, or TF and neuronal sizes was found in this sublayer. Figure Legend:

3. Date of download: 5/31/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease Arch Gen Psychiatry. 1998;55(3):215-224. doi:10.1001/archpsyc.55.3.215 A, Plots of mean neuronal sizes in layers III, V, and VI of prefrontal area 9 in individual brains revealing the range of individual variability and differences between the groups in soma size. Note that significantly smaller neurons are found in pyramidal layer III of schizophrenic (SCHIZ) brains and in layers III and V and marginally in layer VI of Huntington disease (HD) brains. B, Plots of mean neuronal sizes in layers III, IVb, and V in occipital area 17 in individual brains of the control (CTRL) and the schizophrenic group. Sublayer IVb was chosen to be presented because neurons in this sublayer are among the largest cells in area 17. Note that mean soma size does not differ between schizophrenic and control brains (t= −.062, df=82, P=.95). Note the similarity in soma sizes in layers III and V of area 17 and the reduction in soma size in corresponding cortical layers of prefrontal area 9 (A) in schizophrenic brains. Figure Legend:

4. Date of download: 5/31/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease Arch Gen Psychiatry. 1998;55(3):215-224. doi:10.1001/archpsyc.55.3.215 A, Photographs of coronal sections taken at the same magnification from the dorsolateral prefrontal cortex of control (CTRL) (N729), schizophrenic (SCHIZ) (B1702), and Huntington disease (HD) (B194) brains. The positions of cortical probes on the superior frontal gyrus (area 9) are marked by dark bars. B, Photomicrographs of Nissl-stained coronal sections of area 9 from the same 3 brains revealing their cytoarchitectonic features. Note that large pyramidal cells in sublayers IIIc and Va of control area 9 are not present in corresponding layers of the 2 diseased groups. Figure Legend:

5. Date of download: 5/31/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease Arch Gen Psychiatry. 1998;55(3):215-224. doi:10.1001/archpsyc.55.3.215 A, Localization of prefrontal area 9 on the Tailarach and Tournoux stereotaxic atlas of the human brain according to Rajkowska and Goldman-Rakic (with modifications). B, The position of area 17 plotted according to the Brodmann map. Dark bars indicate loci in areas 9 and 17 where measurements were taken. C, Schematic drawing of a cortical probe consisting of an uninterrupted series of 3-dimensional counting boxes. Cell sizes were measured in counting boxes and then divided into individual cortical layers according to cytoarchitectonic criteria established previously. D, Schematic drawing of diameter circle (D-circle), the parameter used to estimate soma size. Figure Legend: