1. ANTI-AGING MEDICINE THE SEVEN BIOMEDICAL PILLARS OF AGING Dr Bill Deagle MD Updated Feb 15 th 2006

2. SEVEN BIOPILLARS OF AGING IN HUMANS 1/ MOLECULAR CONFORMATIONAL CHANGES – FOLDING, CROSSLINKING, AND GLYCOSYLATION 2/ FREE RADICAL OXIDATION OF DNA, PROTEIN, AND FATTY ACIDS 3/ CHRONIC DEFICIENCIES: AMINO ACIDS, ESSENTIAL FATTY ACIDS, MINERALS, VITAMINS, ANTIOXIDANTS 4/ TOXIC LOAD: HEAVY METALS, VOH – VOLATILE ORGANIC CHEMICALS, PAH – POLYAROMATIC HYDROCARBONS, SOLVENTS, ORGANOPHOSPATES, AND TOXIC XENOBIOTIC HORMONE ANALOGUES – E.G. EXONESTROGENS 5] DETOXIFICATION CYP –CYTOCHROME P450, SODs, GLUT PEROX, ACETYLATORS, & PHASE ONE, TWO AND THREE PATHWAYS AND DEFICIENCIES 6/ POLYHORMONE DEFICIENCIES: GH, E1E2E3, PROGESTERONE, TESTOSTERONE, CORTISOL, T3T4, IN WOMEN AND GH, TESTOSTERONE, T3T4, CORTISOL, MELATONIN AND METABOLIC SYNDROME “X” HYPERINSULINISM 7/ PROGRAMMED CELL DEATH: APOPTYSIS INDUCTION AND TELOMERE LENGTH

3. 1/ MOLECULAR CONFORMATIONAL CHANGES – FOLDING, CROSSLINKING, AND GLYCOSYLATION PROTEINS ARE THE STRUCTURAL FOR THE CELLS, TISSUES AND ORGANS FOLDED PROTEINS DON’T WORK ACTIVE ENZYME SITES AREN’T OPEN PROTEINS MISHAPEN BY ATTACHED GLUCOSE DESTROYS FUNCTION

4. 2/ FREE RADICAL OXIDATION OF DNA, PROTEIN, AND FATTY ACIDS TRIAD OF ACIDOSIS (FREE PROTONS), HYPOXIA, AND BIOMOLECULES WITH HOT UNPAIRED ELECTRONS UNBOUND IRON AND OTHER METAL IONS NEEDED FOR FREE RADICAL GENERATION CHAIN REACTION CROSSLINKING 3D CHANGES IN PROTEIN SHAPE, FATTY MEMBRANE FUNCTION, AND MICRO- ORGANELLE STRUCTURE AND FUNCTION

5. 3/ CHRONIC DEFICIENCIES: DIGESTIVE ENZYMES, AMINO ACIDS, ESSENTIAL FATTY ACIDS, MINERALS, VITAMINS, ANTIOXIDANTS GUT LEAKINESS, ENZYME DEFECTS FOR PROTEIN, FAT AND CHO DIGESTION, MINERAL TRANSPORT AND GI TRACT BARRIER TO ACTIVE TRANSPORT OF NUTRIENTS DEFIENCIES COMPOUND CELL AND ORGAN MULTISYSTEM DYSFUNCTION ANTIOXIDANT DEFENSE DEFICIENCIES: INFECTION, CANCER DNA DAMAGE, AND LOSS OF ORGAN FUNCTION

6. 4/ TOXIC LOAD HEAVY METALS, VOH – VOLATILE ORGANIC CHEMICALS, PAH – POLYAROMATIC HYDROCARBONS, SOLVENTS, ORGANOPHOSPATES, AND TOXIC XENOBIOTIC HORMONE ANALOGUES – E.G. EXONESTROGENS HEAVY METALS ALTER THE ENZYME ACTIVE SITES AND THE Km OR MAXIMUM ENZYMATIC REACTIONS OF THE CELL TO MAKE PROTEINS, CELLS STRUCTURES, AND BIOMOLECULES NEEDED FOR CELL FUNCTION. HYDROCARBONS AND CHEMICAL TOXINS INTERFER WITH DETOXIFICATION PATHWAYS, AND CELL MEMBRANES INTERFERRING WITH NUTRIENT TRANSPORT ACROSS CELL WALLS, ENERGY METABOLISM, AND HORMONE SIGNALLING.

7. 5] DETOXIFICATION DETOXIFICATION CYP –CYTOCHROME P450, ADDITION OF ALCOHOL OR OH GROUPS TO TURN NON-POLAR TOXINS INTO POLAR MOLECULES. PHASE ONE, TWO CONJUGATION OR ATTACHING OF OTHER MOLECULES SUCH AS GLUCURONIC ACID, ACETYLATION, AND GLUTATHIONE ATTACHMENT TO ALLOW THE BODY TO ELIMINATE TOXINS IN BILE THROUGH STOOL AND IN THE URINE, AS A POLAR MOLECULE FROM NON- POLAR TOXIN BEFORE PHASE ONE DETOXIFICATION. PHASE THREE PATHWAY POLYMORPHISMS OR DEFECTS IN ONE OR MORE LETTERS OF THE DNA OF THESE KEY DETOXIFICATION ENZYMES ALTERS THE NEED FOR SUBSTRATE NUTRIENTS FOR THESE SYSTEMS TO REMOVE NATURAL CELL GENERATED AND ENVIRONMENTAL TOXINS --- GENOVATIONS LAB, ASHVILLE, N.C., INVADER TECHNOLOGY 98.7% ACCURATE GENE ANALYSIS TO CUSTOM DESIGN PROGRAM OF NUTRIENT SUPPORT TO PREVENT IMBALANCED DETOXICATION WITH BUILDUP OF PHASE ONE OR PHASE TWO BYPRODUCTS.

8. 6/ POLYHORMONE DEFICIENCIES GROWTH HORMONES -- HGH, HUMAN GROWTH HORMONE AND SECONDARY IGF1 – LIVER PRODUCTION OF INSULIN LIKE GROWTH HORMONE ONE LEVELS, NEEDED FOR HEALING AND TISSUE REPAIR IN ALL ADULTS OF ALL AGES SEX HORMONES – FEMALE --E1E2E3, PROGESTERONE, NEEDED FOR PERIMENOPAUSE LASTING 9 TO 14 YEARS IN FEMALES, WITH PARTIAL DEFICIENCY TO MENOPAUSE INDEFINITELY SEX HORMONES MALE -- TESTOSTERONE, MALE MENOPAUSE PROTECTION OF HEART, BLOOD VESSELS, BRAIN AND REDUCTION IN BENIGN ENLARGMENT OF PROSTATE CAUSED BY REFLEX INCREASE IN BRAIN FSH AND LH WHICH WOULD OTHERWISE STIMULATE PROTATE GROWTH. ADRENAL -- CORTISOL, ALDOSTERONE – GENERAL DROP, DHEA IS PROTECTIVE OF BRAIN, BLOOD VESSELS, MUSCLE MASS AND BONE MASS, AND PARTICULARLY IMPORTANT IN DIABETICS AND OBESE. THYROID -- T3T4, IN WOMEN AND GH, TESTOSTERONE, T3T4, CORTISOL, MELATONIN AND METABOLIC SYNDROME “X” HYPERINSULINISM

9. 7/ PROGRAMMED CELL DEATH APOPTOSIS INDUCTION AND TELOMERE LENGTH NEMATODE RESEARCH IN PREVENTION OF TELOMERE SHORTENING BY SPECIAL DNA TELOMERASE BLOCKER MOLECULES AND NANOTECHNOLOGIES IN FUTURE. NUTRIENT PREVENTION OF APOPTOSIS DRUG AND NANOTECHNOLGIES TO PREVENT APOPTOSIS GLYCONUTIENT SUPPLEMENTATION OF 8 ESSENTIAL GLYCONUTRIENT SUGARS FOR CELL SURFACE TO DNA TO PREVENT CELL DEATH --- AMBROTOSE FROM MANNATECH INC.

10. Top Antiaging Strategies Examples 1 Glycosylation  Sportron Carbotone 2 DNA Free Radicals  Xango 3 Chronic Deficiencies  URI Complete Food 4 Toxin & Heavy Metals  NCD Natural Cellular Defense zeolite oral chelator 5 Detoxification  Bio Cleanse for Phase I & II 6 Polyhormone Imbalances  IndiumEase 7 Tissue Rejuvenation  Stem Enhance stem cell releaser