1. Lipids

2. Lipids – Macromolecule #1
Made up of C, H, and a little bit of O
This group has fats and oils (including phospholipids), and steroids
They are not water soluble
*STOP AND THINK: Write down your answers for the following
What does that mean?*
How might that be useful for something like a cell membrane?*
-What does it mean to be not water soluble? You can show a toy that has two layers (due to solubility) or an oil/vinegar salad dressing, or talk about if someone has ever gotten pitch on their hands before and if they tried to rinse it off their hands…what works when trying to get pitch off your hands? Peanut butter  (another lipid-soluble substance)
-How could it be useful? Can help to act as a barrier to things like water or water soluble substances…they may not get this…but maybe worth a shot?

3. Fats & Oils Structure: Function:
Glycerol + fatty acids
Fatty acids are chains of carbon atoms bonded to hydrogen atoms
Saturated vs. Unsaturated
Function:
Store large amounts of chemical energy
Main component in cell membranes
E.g. Triglycerides (i.e. Olive Oil, Beef Fat)
How might these molecules become bonded together?? Dehydration Synthesis!! (this is stated in the next slide)

4. Fats & Oils: Structure Glycerol
Many lipids contain 3 fatty acids bonded to the glycerol
Called triglycerides
These fatty acids are bonded to the glycerol via dehydration synthesis
(*Animation*)
Fatty Acid 1
Fatty Acid 2
The fatty acids do not need to all be the same kind. They can also be saturated, unsaturated, or polyunsaturated. What do you notice about the differences between the three fatty acid chains shown here?
Should we tell them to kink the double bonded areas or not yet?
**ANIMATE THIS so it labels these…and then goes away and asks them to draw it in their notes.
Fatty Acid 3
Glycerol

5. Now draw this triglyceride in your notes

6. Fatty Acids Fatty acids have long hydrocarbon chains Twig:
Hydrocarbons

7. Hydrocarbons
There is a shorthand for drawing this part of the fatty acid chains
To simplify a hydrocarbon, we draw a kinked line
Each bend or end of a line is a carbon atom
Stearic acid is mainly used in the production of detergents, soaps, and cosmetics such as shampoos and shaving cream products. 

8. Practice Shorthand for Hydrocarbons
Try drawing the two molecules below:
Chemical Name
Ethanol
Heptane
Chemical Formula
Ball & Stick Model
Abbreviated (Shorthand)
Model
C2H5OH
C7H16
Heptane is found in gasoline OH

9. Example Triglyceride Sketch
Now draw The triglyceride
in your notes USING THE SHORTHAND METHOD

10. Saturated vs. Unsaturated
A lipid’s function can be affected by the saturation of the fatty acids
Saturated: it is “saturated” with hydrogen atoms (maximum number of hydrogen, every spot filled).
Unsaturated: at least one double bond between carbon atoms thus the chain has fewer hydrogen.

11. Saturated vs. Unsaturated
Saturated fats are solid at room temperature and unsaturated fats are liquid.
Saturated fats are found in animals
E.g. butter and meat.
Unsaturated fats are found in plants
E.g. olive or peanut oils.
Based on their structure (right) can you guess why saturated fats are solid and unsaturated are liquid at room temp? Share with a neighbor.
Can use a deck of cards to show how the molecules stack together – bend some of the cards to show the unsaturated fatty acids.

12. “Butter Manatee and Diver” sculpted by Jim Victor, Palmetto, FL Manatee County Fair, Jan. 2012
Anyone eat straight butter as a child? Ms. Turner’s family had to hide the butter…she would climb up on the counter and scoop it out with her hands. 

13. Natural peanut butter can separate into both types!
Unsaturated
Saturated

14. Saturated vs. Unsaturated
Saturated and unsaturated fats have different properties because of how the molecules pack together.
Which molecule do you think would pack together more closely?

15. Saturated vs. Unsaturated
Unsaturated fatty acids have lower melting points than saturated fatty acids.
What does it mean to melt on a molecular level? What would that look like?
If molecules are stacked closer to each other do you think the substance would melt faster or slower?
Note that as a group, the unsaturated fatty acids have lower melting points than the saturated fatty acids.
The reason for this phenomenon can be found by a careful consideration of molecular geometries. The tetrahedral bond angles on carbon results in a molecular geometry for saturated fatty acids that is relatively linear although with zigzags. See graphic on the left.
This molecular structure allows many fatty acid molecules to be rather closely "stacked" together. As a result, close intermolecular interactions result in relatively high melting points. (MEANING it is harder to get them moving and away from each other…the more moving a.k.a. kinetic energy, the more “melting”….thus if they have strong interactions it is harder to get the substance to melt).
On the other hand, the introduction of one or more double bonds in the hydrocarbon chain in unsaturated fatty acids results in one or more "bends" in the molecule. The geometry of the double bond is almost always a cis configuration in natural fatty acids. These molecules do not "stack" very well. The intermolecular interactions are much weaker than saturated molecules. As a result, the melting points are much lower for unsaturated fatty acids. (If they have weak interactions it is easier to break them away from each other and get them moving!)

16. How would the bottom 3 fatty acids look different from stearic acid?
Of the 4, which one would be able to pack together the most?
THUS, which melting point would be highest???
Share your thoughts with your neighbor! Don’t forget to give them time to think it out on their own. 
stearic acid
oleic acid
linoleic acid
linolenic acid
stearic acid
m.p. 70ºC
oleic acid
m.p. 16ºC
linoleic acid
m.p. -5ºC
linolenic acid
m.p. -11ºC

17. Melting Point Wrap-Up
THINK, PAIR, SHARE: What statement can you make about the relationship between the number of double bonds in fatty acid chains and its melting point?
What evidence could you gather to support your claim?
stearic acid - m.p. 70ºC
oleic acid - m.p. 16ºC
linoleic acid - m.p. -5ºC
linolenic acid - m.p. -11ºC

18. Saturated vs. Unsaturated Fatty Acids in Fats and Oils
THINK, PAIR, SHARE:
If you want the most unsaturated fatty acids in your diet, which is the most healthy oil you should use the most?
Which fat or oil contains the most saturated fatty acids?
Most unsaturated fatty acids = olive oil
Most saturated fatty acids = beef fat

19. Phospholipid
Cell membranes are made up of a lipid similar to triglycerides; a phospholipid
Structure: Glycerol backbone attached to a phosphate group “head” and 2 fatty acid “tails”
The tails can be saturated or unsaturated
(*Animation*) About 80% of the way down…
Function: Provide a selective barrier between the inside and outside of the cell and cellular compartments.

20. in your notes USING BOTH Methods
Phospholipid
draw The Phospholipid
in your notes USING BOTH Methods

21. How we will picture a Phospholipid

22. Steroids Structure: Function: 4 interconnected rings
Aids in fluidity/flexibility of cell membrane (cholesterol)
Hormones that act as signaling molecules (i.e. testosterone and estrogen)
Cholesterol works similar to unsaturated fatty acid chains in phospholipids. They make it harder for the phospholipids to pack together thus increasing the fluitidy.
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23. Hormones = Signaling Molecules
Androgens
(male sex hormones)
Produced in the testes
Responsible for development of male sex characteristics
Estrogens
(female sex hormones)
Produced in the ovaries
Responsible for development of female sex characteristics
Cortisone Hormones
Produced in the adrenal cortex
Regulate metabolism of carbohydrates, decrease inflammation, involved in reaction to stress
Someone who dresses “androgenous” is a female dressing more masculine i.e. wearing a suit jacket and tie.

24. Let’s Fill in Your Macromolecule Table for Lipids!
Types of Atoms
Monomers made of
Function(s)
Examples
Sketch