1. Scientific, Technological and Industrial Applications 10-11 June 20091IFIMED'09 Symposium

2.  Medical Accelerators:  CNA Sevilla  CIEMAT Madrid  IFIMED Valencia  Applications: Radiobiology  Industrial Participation Outline 10-11 June 20092IFIMED'09 Symposium

3. CNA Sevilla 10-11 June 20093IFIMED'09 Symposium

4. CNA is:  A research centre.  A user facility (ICTS) open to the research of external scientists.  A laboratory which provides advanced scientific services.  A good environment for the training of scientists and technicians.

5. Objectives and research lines Objectives and research lines  Materials science  Nuclear science and technology.  Accelerator mass spectrometry (AMS)  Production of PET isotopes and bio- medical research.

6. Accelerators in CNA  Tandem van de Graaff, 3MV  Tandetron, 1MV  Ciclotron, 18MeV (protons), 9MeV (deuterons)

7. Opportunities in medical physics  PET imaging (Micro PET – SPECT)  Radio-pharmacy research (Cyclotron) (FDG, FLT, F-Dopa)  Micro-PIXE analysis (Microprobe in Tandem)  Pu determination in urine  14C marked molecules to track metabolism.  Irradiation tests (Cyclotron external line)

8. Analysis with the microprobe: Osteoporosis evolution after estrogen therapy: Ca, P concentrations in bones Osteoporosis evolution after estrogen therapy: Ca, P concentrations in bones Alzheimer disease: Heavy metal accumulation in neurons

9. Radio-pharmacy Biomolecules marked with 18 F, 11 C, 13 NH 3 y H 2 15 O used for research and diagnostics CNA provides FDG to PET centers. Contract with andalousian Health service.

10. PET & SPECT scanners for small animals

11. El CNA es una instalación nacional (ICTS) abierta a la comunidad científica española e internacional. La comunidad española de física nuclear puede beneficiarse del uso del CNA. http://www.centro.us.es/cna/ cna@us.es

12. CIEMAT Madrid 10-11 June 200912IFIMED'09 Symposium

13. IFIMED09 11-Junio-2009 13 THE ACCELERATOR UNIT AT CIEMAT: THE GROUP In the year 2008, CIEMAT created a Particle Accelerators Unit with 27 people up to now. It absorbs the former Applied Superconductivity Group and the facilities located at another Institute, CEDEX SCHEME OF THE ACCELERATOR UNIT

14. IFIMED09 11-Junio-2009 14 THE ACCELERATOR UNIT AT CIEMAT: THE SITE FACILITIES AT CEDEX FACILITIES AT CIEMAT (Buildings 7 y 8)

15. IFIMED09 11-Junio-2009 15 ACTIVITIES & DEVELOPMENTS IN ACCELERATORS GENERAL PROJECTS IN WHICH THE UNIT IS INVOLVED * Since a long time ago, our Unit is involved in many projects related to Particle Accelerators from previous activities started at the superconductivity group. Most of them consists of developments of prototypes and short series for different facilities.

16. IFIMED09 11-Junio-2009 16 ACTIVITIES & DEVELOPMENTS IN ACCELERATORS * The CIEMAT Accelerator Unit participates in a project with other partners for the development and fabrication of a racetrack microtron for Intra Operative Surgery. It is a 12 MeV, 1 µA, machine for which the Unit is developing the LINAC. MEDICAL PHYSICS:RACETRACK MICROTRON Accelerating Cavity and Electrical Field Distribution Scheme of the working principle for a “Racetrack” Microtron Conceptual Design of the LINAC 1.-Electron Gun 2.-Injection Magnet 3.-LINAC 4&5.- End Magnets 6.- Correcting Dipoles 7.- Quadrupole 8.- Extraction Magnet 9.- Extracted Beam

17. IFIMED09 11-Junio-2009 17 ACTIVITIES & DEVELOPMENTS IN ACCELERATORS MULTIPURPOSE: THE CIEMAT LINAC CIEMAT is considering to develop and install a multipurpose accelerator, to study some of the applications presented in this table. The initial study has been performed by Iberdrola with the collaboration of the IAP (Frankfurt) in the framework of a project funded by CDTI. Different alternatives will be analyzed, including the superconducting option, similar to the SARAF facility. Superconducting Linac at SARAF Facility

18. IFIMED09 11-Junio-2009 18 FACILITIES: SUPERCONDUCTIVITY LABORATORY * Our unit runs two specialized laboratories. One is the Superconductivity lab, which is located at CEDEX and it is the place where superconducting magnets and devices are tested. It includes power supplies up to 2000 A, two cryostats for Low Tc magnets and one for HTc ones, using a cryocooler. We also have the necessary instrumentation to carry out the tests. The lab is completed with a winding facility to manufacture magnets, which is located at CIEMAT. Superconductivity Laboratoty at CEDEXWinding Facility at CIEMAT

19. IFIMED09 11-Junio-2009 19 FACILITIES : ENERGY LABORATORY * The second Lab is devoted to Energy. It has a pit to test flywheels at nominal speed, power and energy. The installed power is 500 kVA and it also has a 16 T crane plus a control room. In this lab we assemble and test power converter and supplies. Energy Laboratory at CEDEX

20. IFIMED09 11-Junio-2009 20 FACILITIES : ASSEMBLY HALL * Finally, we also have an assembly Hall where also wind coils for magnets, perform heat and cleaning treatments and assemble the devices, that we have to deliver to the different collaborations. Assembly Hall at CEDEX

21. IFIMED Valencia 10-11 June 200921IFIMED'09 Symposium

22. 10-11 June 2009IFIMED'09 Symposium22 The Accelerator complex IFIMED Angeles Faus-Golfe IFIC-Valencia Basic Installation for Protontherapy: Beam Production System Beam Transport System Gantry rooms and Nozzle Fixed Beam Treatment room Experimental room Accelerator R&D Beam Instrumentation Cyclinacs applications

23. 10-11 June 2009IFIMED'09 Symposium23 Basic Installation for Protontherapy: IFIMED Cyclotron (turn-key-system) Courtesy of IBA and Unitat Tecnica UV

24. 10-11 June 2009IFIMED'09 Symposium24 IFIMED Monitoring of secondary beam: beam position and size Accelerators R&D: Beam Instrumentation In collaboration with:

25. 10-11 June 2009IFIMED'09 Symposium25 IFIMED Accelerators R&D: Cyclinacs applications Collaboration with TERA to develop competence in accelerator research by building and testing in the IFIMED with 230 MeV protons, an accelerating module similar to the first of CABOTO: Carbon Boooster for Therapy in Oncology Courtesy of TERA Foundation

26. Applications: Radiobiology 10-11 June 200926IFIMED'09 Symposium

27. Angel Ayuso-Sacido, PhD Garcia-Verdugo´s Lab Instituto Cavanilles -UVEG Centro de Investigacion Principe Felipe New York Brain Tumor Center Weill medical College of Cornell Biological Application of Proton Beam: Translational research in tumour treatment IFIMED. Valencia. June 11th, 2009

28. 1. Molecular pathways underlying the biological effect of Proton Beam Therapy 2. To examine the middle and long term evolution of healthy tissue in treated experimental models. 3. To evaluate functional changes and behaviour disfunction due to the treatment. (memory and learning disfunction, myelination problems) Research on the biological effects of proton beam therapy Translational research in tumour treatment a. Apoptosis induction in tumour cells b. Expression pattern of Chemokines c. DNA alteration in healthy cells that might transform them into tumour cells

29. Translational research in tumour treatment

30. Type B cells: SVZ Astrocytes Type C cells: Rapidly dividing transit amplifying Type A cells: Committed migratory neuroblastsAdult Neural Stem Cells Subventricular Zone (SVZ) of the lateral ventricle organization Adapted from Alvarez-Buylla A and Lim DA. 2004 Translational research in tumour treatment

31. 2 months2 years Translational research in tumour treatment

32. 1. So far, Neurogenic niches are not considered an area to be protected from radiation. 2. Destruction of Neurogenic niches might be responsible for memory, learning, and myelination problems after radiation treatments. 3. Research is needed in children undergoing radiation treatment as well as in experimental models. Summary Translational research in tumour treatment

33. Industrial Participation 10-11 June 200933IFIMED'09 Symposium

34.  VARIAN Medical systems: turn key PT centers  IBA: turn key PT centers  AVS: engineering and construction of instrumentation for accelerators and space UHV (CERN, ESA, ISIS,…)  Acciona Infraestructuras: design, study and construction of nuclear plants, large infrastructures, hospitals…  Felguera Construcciones mecanicas: large mechanical infrastructures: gantries, vacuum Vessels (IBA, CERN, XFEL,…) 10-11 June 200934IFIMED'09 Symposium

35.  TRINOS Vaccuum projects: engineering and construction of instrumentation for accelerators and space UHV (CERN, ESRF, CIEMAT, IFIC…)  TELSTAR: engineering and construction of instrumentation for accelerators and space UHV (ESRF, ALBA…)  JEMA: “customized” power supplies (CERN, DESY, RAL,…)  CT-RAD: design, study and construction of radiation barriers, bunker… (special concrete) (ALBA, CIEMAT, IVO Cuenca,…) 10-11 June 200935IFIMED'09 Symposium

36. Thanks for your attention I acknowledge: all the companies, the lab’s and specially to CDTI for his support and contribution in the organization of this session 10-11 June 200936IFIMED'09 Symposium

37. 10-11 June 200937IFIMED'09 Symposium