1. 0 International Medical Cluster (IMC), to be established in Moscow, creates a unique framework for developing healthcare business: –IMC activities are regulated by a separate Federal Act 160-FZ «On International Medical Cluster», –The Cluster is aimed at creating advanced healthcare delivery patterns, supporting development of new drugs and medical devices, and employing international best practices in medical education and research –In accordance with the legislation, special conditions in terms of using OECD standards and employing foreign experts are provided for project participants. At the moment the main focus of interest is placed on attracting investors and operators for a wide range of medical services, educational and R&D programs IMC is to be located on 57.6 ha territory at the Skolkovo premises. Total infrastructure area - 450.000 sq.m. IMC Project: General Overview

2. 1 Cooperation Directions Introducing advanced healthcare delivery patterns based on international best practices Supporting commercialization of new drugs, technologies and medical devices in Russia and abroad Engaging international experts to develop educational activities and research in healthcare Enhancing international cooperation in the healthcare domain GOALS International Medical Cluster (IMC) is focused on healthcare development in Moscow, encompassing the most up-to- date international best practices and sector trends in Russia VISION

3. 2 IMC Fund provides wide range of services to support Cluster participants IMC provides its participants with various benefits IMC mission - healthcare development in Moscow, encompassing international best practices and sector trends in Russia Federal Act 160-FZ: Unique Framework for Business Development Support from the Moscow Government Special conditions for project participants Healthcare Innovations Community

4. 3 “Three Wheels” of the Cluster Education R&D and Startups Care & Patients

5. 4 Education Healthcare Services Main Focus: Attracting Investors and Operators DirectionExamples of cooperation models Educational programs, for instance: –Simulation center –Lifelong learning and professional development programs for doctors and paramedical staff Wide range, from separate elements to multifunctional clinic: –Laboratory services –Check-up diagnostic center –Cardiovascular disease treatment clinic An important requirement is attracting international expertise and establishing international partnership Operators and partners: examples International partner clinic Different medical services providers Medical devices manufacturers International medical universities R&D Applied research programs, for instance: –Phases 1 and 2 clinical trials –New treatment practices and standards Pharmaceutical companies Medical devices manufacturers Examples of cooperation models – not a comprehensive list

6. 5 Рабочая (не финальная) версия материалов Lifelong learning based on international quality standards Business trainings and seminars Clinical simulation center for skills development MBA in Healthcare Management Higher education General practice retraining programs Medicine residency training program in cluster clinics Postgraduate education On-site trainings/ Certification International medical exchange programs for doctors and managers Medical curriculum based on international quality standards 1 Healthcare Management program 2 3 4 5 Paramedical staff retraining programs 6 7 8 9 Professional development 10 11 Eliminating Educational Gaps: Opportunities (Long List) LONG LIST DoctorsNursesManagers DRAFT VERSION

7. 6 Рабочая (не финальная) версия материалов Eliminating Educational Gaps: Opportunities (Short List) OpportunityStrategic relevance FeasibilityCompetition Attractive opportunity, short term program Непривлекательная возможность Limited relevance to cluster goals Large faculty requiredBroad offer Limited relevance to cluster goals Additional resources required Limited offers High demand for training of IMC doctors IMC clinical baseMany offers, low quality High demandIMC international partnersInsufficient offer Unfilled demand Local and international partnership required Insufficient offer, low quality High demand for well trained IMC nurses IMC international competence Lack of offers High demand Sufficient IMC resources and competence High competition, lack of international experts No competence Lack of high quality offers High demand for good quality Good clinical base Demand for internationally oriented programs Sufficient IMC competence Mid-range offer, might be diversified in terms of quality High market demand International practices and partnership Insufficient offer FILTERING CRITERIA Highly attractive Not attractive Medical curriculum Healthcare Management program Medicine residency training program Medical exchange program MBA in Healthcare Management Paramedical staff retraining program Simulation center General practice retraining program Lifelong learning program Professional development program Business trainings and seminars 1 2 3 4 5 6 7 8 9 10 11 FILTERING CRITERIA Potentially attractive opportunity (long term prospective) Attractive opportunity, long term program DRAFT VERSION

8. 7 Рабочая (не финальная) версия материалов Segment not relevant to some selection principles Market sectors Research/ generating ideas Clinical trials/ product development Market entry/ continuing research Pharmacy and biotechnology Segment not relevant to some selection principles Medical devices Segment not relevant to some selection principles Medical services IT in healthcare -- IMC relevant segments Personalized care Medical services segment should be fully covered to implement focus-on-patient-needs principle I II I III -- principles which explain relevance for IMC Healthcare products/ services creation chain Clinical trials and product development – R&D priority, according to principles of integration and inorganic growth Step 1: 6 segments for further IMC development Translational Medicine Prevention – Care – Rehabilitation DRAFT VERSION

9. 8 Рабочая (не финальная) версия материалов IT in healthcare Pharmacy and biotechnology Medical devices Medical services Research/ generating ideas Clinical trials/ product development Market entry/ continuing research Healthcare Market Structure Healthcare products/ services creation chain НИОКР R&D «Chessboard»: two dimensions DRAFT VERSION

10. 9 D1 D4 IMC Projects in Skolkovo Innovation Center IMC territory Total IMC area 57,6 ha Total IMC objects area 450 000 sq.m. IMC LocationsЗемельные участки D1 zone and D4 zone Land areas of D1 zone Land areas of D4 zone D1 zone D4 zone

11. 10 Pilot Facilities: Concept Diagnostic facility – approx. 13 000 sq.m. including: –"Check Up“ diagnostic center – approx. 3 000 sq.m. –Training simulation center and conference center – approx. 1 600 sq.m. –Support infrastructure – approx. 8 400 sq.m. Stage 1 facilities To be determined. Total area – approx. 28 000 sq.m. Stage 3 facilities Therapeutical facility – approx. 19 000 sq.m. Stage 2 facilities STAGE III STAGE I ЭКСПЛИКАЦИЯ: 1(а). Диагностический корпус (общ. площадь – 12 888 м2) 1(б). Терапевтический корпус (общ. площадь – 19 062 м2) 2. Третья очередь строительства(общ. площадь – около 28 000 м 2 ) 3. Кислородная газификационная станция 4. Проектируемый паркинг P3 STAGE II

12. 11 Pilot Facilities: Visualization Stage 1 Diagnostic facility Stage 2 Therapeutical facility Stage 3 To be determined

13. Appendix

14. 13 В настоящий момент определено три приоритетные модели для возможного дальнейшего развития ММК в области мед.учреждений Терапевтическая область Основные проблемные области в России Приоритизированные медицинские модели для ММК Сердечно-сосудистые заболевания Ишемическая болезнь сердца Ишемический инсульт Геморрагический инсульт Кардиомиопатия и миокардит Лечение и реабилитация сердечно- сосудистых и нейро-сосудистых заболеваний (вкл. инсульт) 1 Ортодепия и Травматология Лечение и реабилитации в области ортопедии и травматологии (вкл. боли в пояснице и шее) 3 Неврологические расстройства Дополнение онкологической клиники2 Новообразования Психические расстройства Мигрень Головная боль от злоупотребления медикаментами Болезнь Альцгеймера и другие виды деменции Боль в пояснице и шее Падения Травмы в результате ДТП Самоповреждение Межличностное насилие Остеоартрит Ревматоидный артрит Основные области потребностей будут определяться в синергии с текущими услугами пилота Депрессивные расстройства Расстройства, вызванные злоупотреблением алкоголя Тревожные расстройства Шизофрения Биполярное расстройство