Presentation is loading. Please wait.

Presentation is loading. Please wait.

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.

Published byLuke Mervin Logan Modified over 5 years ago

Similar presentations

Presentation on theme: "Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic."— Presentation transcript:

1 Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms  Christian Reeps, MD, Markus Essler, MD, Jaroslav Pelisek, PhD, Stefan Seidl, MD, Hans-Henning Eckstein, MD, Bernd-Joachim Krause, MD  Journal of Vascular Surgery  Volume 48, Issue 2, Pages (August 2008) DOI: /j.jvs Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 An 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography of abdominal aortic aneurysm (AAA) vessel wall at maximum focal FDG uptake in a 66-year-old woman with a symptomatic AAA (maximum diameter, 50 mm; maximum standard uptake value, 9.1). Panel a, coronal section. Panel b, transversal section; arrow, effusive aortic FDG uptake with spillover effect. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Average maximum standard uptake values (SUVmax) of the control group compared with patients with asymptomatic and symptomatic abdominal aortic aneurysms (AAAs). Both, asymptomatic and symptomatic patients showed significant increase in uptake values compared with controls, with highest SUVmax levels in the symptomatic AAAs. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Histologic results to the corresponding 18F-fluorodeoxyglucose uptake of positron emission tomography/computed tomography from Fig 1. Panel a, Hematoxylin and eosin staining; arrow, inflammatory infiltrates. Panel b, Elastin von Gieson staining; arrows, collagen (red) and elastin (black) fibers in the tunica media; Panel c, CD68 antibody staining (brown); arrow designates CD68-positive cells with dens transmural infiltration; Panel d, CD3 antibody staining (brown); arrow designates CD3-positive cells; Panels e and f, Matrix metalloproteinase (MMP) -2, MMP-9 antibody staining (brown); arrow designates positive cells); Panel g, Smooth muscle actin antibody staining (red); arrow designates rarified smooth muscle actin–positive cells. Original magnification, 50×. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Scatter plot of maximum standard values (SUVmax) of fluorodeoxyglucose F18 uptake compared with (A) inflammatory cell infiltrate, (B) matrix metalloproteinase (MMP)-2 and -9 activities, and (C) content of elastin, collagen, and vascular smooth muscle cells (VSMC) in the corresponding area of abdominal aortic aneurysm (AAA) vessel wall. Cell densities were semiquantitatively determined and scored from 0 to 6+. Increasing SUVmax correlated significantly with higher densities of (A) inflammatory infiltrates and (B) MMP-2 or MMP-9. C, Negative correlation was found for collagen and VSMCs but not for elastin. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Download ppt "Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic."

Similar presentations

Large renal artery aneurysm in Takayasu arteritis

Large renal artery aneurysm in Takayasu arteritis
Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice  Ryotaro Hashizume, MD, Aika Yamawaki-Ogata,

Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice  Ryotaro Hashizume, MD, Aika Yamawaki-Ogata,
Decellularized vein as a potential scaffold for vascular tissue engineering  Patrick J Schaner, MD, Niels D Martin, MD, Thomas N Tulenko, PhD, Irving M.

Decellularized vein as a potential scaffold for vascular tissue engineering  Patrick J Schaner, MD, Niels D Martin, MD, Thomas N Tulenko, PhD, Irving M.
Ruptured femoropopliteal artery aneurysms in von Recklinghausen neurofibromatosis  Fabian Gutarra, MD, Javier Rodriguez Asensio, MD, Miguel Miceli, MD,

Ruptured femoropopliteal artery aneurysms in von Recklinghausen neurofibromatosis  Fabian Gutarra, MD, Javier Rodriguez Asensio, MD, Miguel Miceli, MD,
Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in.

Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in.
Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats 

Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats 
Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats  Zhenhai Yu, MD, Keisuke.

Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats  Zhenhai Yu, MD, Keisuke.
Hyperglycemia limits experimental aortic aneurysm progression

Hyperglycemia limits experimental aortic aneurysm progression
Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S

Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S
Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix  Sung Shin, MD, Yong-Pil.

Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix  Sung Shin, MD, Yong-Pil.
Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation  Matthew J. Eagleton, MD,

Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation  Matthew J. Eagleton, MD,
Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers  Rob Hurks, MD, PhD, Rogier H.J. Kropman,

Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers  Rob Hurks, MD, PhD, Rogier H.J. Kropman,
Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.

Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.
Markers of instability in high-risk carotid plaques are reduced by statins  Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

Markers of instability in high-risk carotid plaques are reduced by statins  Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.
A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis 

A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis 
Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm.

Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm.
Karen M. Newman, PhD, Jessie Jean-Claude, MD, Hong Li, MS, John V

Karen M. Newman, PhD, Jessie Jean-Claude, MD, Hong Li, MS, John V
Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk  Moritz Lindquist.

Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk  Moritz Lindquist.
Renal artery stenosis and aneurysms associated with neurofibromatosis

Renal artery stenosis and aneurysms associated with neurofibromatosis
Veysel Kutay, MD, Cevat Yakut, MD, Hasan Ekim, MD 

Veysel Kutay, MD, Cevat Yakut, MD, Hasan Ekim, MD 

Similar presentations

Ads by Google